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| 146877 | 114797 | COVID19(2023년) | host | Term | host | abstract | 숙주 | 32814 | https://doi.org/10.1016/j.lpm.2022.104131 | Covid-19, an unfinished story | Yves Buisson | 202209 | Mini review | Sciencedirect | Abstract!!The Covid-19 pandemic appeared in China in December 2019 as a cluster of transmissible pneumonia caused by a new betacoronavirus. On March 11, 2020, the World Health Organization (WHO) declared it a pandemic. Covid-19 is a mild infection in 80% of cases, serious in 15% and critical in 5%. Symptomatic forms include a first phase of flu-like viral invasion, and at times a second phase, dysimmune and inflammatory, with acute respiratory distress syndrome, multiorgan failure and thromboembolic complications. Degree of severity is related to age and comorbidities.!!SARS-CoV-2 is the third highly pathogenic Betacoronavirus to cross the species barrier. Its genome, an RNA of 29,903 nucleotides, shows strong homogeneity with bat coronaviruses from southern China, but the conditions for its passage in humans have yet to be elucidated. Mutations can give rise to variants of concern (VOC) that are more transmissible and able to evade the host's immune response. Several VOCs have succeeded and replaced one another: Alpha in October 2020, Beta and Gamma in December 2020, Delta in spring 2021 and Omicron in November 2021. The Covid-19 pandemic has evolved in five waves of unequal amplitude and severity, with geographical disparities. Worldwide, it has caused 395,000,000 confirmed cases including 5,700,000 deaths.!!Epidemiological surveillance applies several indicators (incidence rate, test positivity rate, effective R and occupancy rate of intensive care beds) supplemented by genomic monitoring to detect variants by sequencing.!!Non-pharmacological measures, particularly face mask wearing, have been effective in preventing the transmission of SARS-CoV-2. Few currently available drugs have proven useful, with the exception of dexamethazone for patients requiring oxygen therapy. Development of SARS-CoV-2 vaccines began early on many platforms. Innovation was brought about by the Pfizer-BioNTech and Moderna messenger RNA vaccines, which claim protective efficacy of 95% and 94.1% respectively, far higher than the 70% minimum set by the WHO.!!Governments have hesitated between two strategies, mitigation and suppression. The second has been favored in critical periods such as April 2020, when 2.5 billion people throughout the world were confined. Vaccination campaigns got underway at the end of December 2020 and progressed without reaching sufficient herd immunity, leading some nations to consider compulsory vaccination or to require a vaccine or health pass, in order for persons to access different activities.!!Will the pandemic stop with Omicron and become endemic? This part of the Covid-19 story remains to be told. | 2566 | La Presse M?dicale | ||||
| 352106 | 114797 | COVID19(2023년) | health | Term | health | title | 건강 | 239580 | https://doi.org/10.1016/j.explore.2022.03.007 | The second pandemic: Mental health | Angie Lillehei | 202205 | pubmed | None | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/8935974/ | 2541 | EXPLORE | ||||
| 7018 | 114797 | COVID19(2023년) | evaluated | Action | evaluated | abstract | 232641 | https://doi.org/10.1016/j.encep.2021.03.002 | Bio-psychosocial study on the impact of the COVID-19 lockdown on depression and anxiety in a sample of 1753 French-speaking subjects | B Gouvernet|||M Bonierbale | 202204 | pubmed | The aim of this article was to study the impact of the COVID19 lockdown on anxiety and depressive symptoms on the basis of responses to an online survey from 1753 French-speaking subjects, conducted between April 27 and May 11, 2020. !!{{ Method: }} Using a biopsychosocial model, the effects of socio-demographic characteristics (age, gender at birth, socio-professional category, sexual orientation), lockdown conditions (material factors: urban density of the place of residence, surface area of the place of residence during lockdown), social characteristics: living with a partner during lockdown, presence of children during lockdown) and psychosocial history (attachment styles) on anxiety - evaluated on the GAD7 - and depression - evaluated on the MDI - were investigated. Ordinal regression analyses were conducted. !!{{ Results: }} The rates of depression observed (moderate or severe depression: 22.5%) and anxiety (moderate or severe anxiety: 18.4%) were higher than usual but lower than what has been documented in other studies on the effects of lockdown. Women appeared to be more vulnerable than men (Anxiety: AOR=1.647, CI 95%=1.647-2.530; Depression: AOR=1.622, CI 95%=1.274-2.072). Bisexual individuals had an increased likelihood of anxiety symptoms (AOR=1.962, CI 95%=1.544-2.490) and depression (AOR=1.799, CI 95%=1.394-2.317). For homosexuals, only links with depression were observed (AOR=1.757, CI 95%=1.039-2.906). People in a situation of economic vulnerability were more prone to anxiety disorders (e.g. people with no working activity: AOR=1.791, CI 95%=1.147-2.790) or depression (e.g. people with no working activity: AOR=2.581, CI 95%=1.633-4.057). Links with attachment styles were also found. Fearful subjects were particularly vulnerable (anxiety: AOR=2.514, CI 95%=1.985-3.190; depression: AOR=2.521, CI 95%=1.938-3.289), followed by subjects with an anxious attachment style (anxiety: AOR=1.949, CI 95%=1.498-2.540; depression: AOR=1.623, CI 95%=1.207-2.181). The impact of lockdown on avoidant subjects only concerned depression (AOR=1.417, CI 95%=1.034-1.937). Being with a partner during lockdown appeared to have a protective effect against depression (AOR=.693, CI 95%=.555-.866). Neither the presence of children, the surface area of the lockdown residence, nor the population density of the place of residence was associated with anxiety or depression. !!{{ Conclusion: }} The impact of lockdown on mental health depends on a range of dimensions that need to be apprehended in order to tailor post-lockdown psychological and social support. Management based on a biopsychosocial approach should be favored. | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/8015427/ | 2449 | L'Enc?phale | |||||
| 1171 | 114797 | COVID19(2023년) | SARS-CoV-2 | Virus | SARS-CoV-2 | title | 제2형 중증급성호흡기증후군 코로나바이러스 | 37452 | https://doi.org/10.1038/s41592-022-01448-9 | Fighting SARS-CoV-2 with structural biology methods | 202204 | Comments & Opinion | Nature | 888 | 1548-7091 | Nature methods | New York, NY : Nature Pub. Group | ||||
| 1113 | 114797 | COVID19(2023년) | pandemic | Term | pandemic | abstract | 범유행_전염병 | 33227 | https://doi.org/10.1016/j.radi.2021.09.009 | COVID-19: A literature review of the impact on diagnostic radiography students | D. Astirbadi|||P. Lockwood | 202205 | Review article | Sciencedirect | Abstract!!Introduction!!COVID-19 is a highly contagious viral disease declared a global pandemic in March 2020. Throughout the pandemic, radiography students have been working in hospitals on the frontline. The review aimed to search for evidence of the impact COVID-19 has had on diagnostic radiography students and consider whether additional support and learning needs to be implemented.!!Methods!!A literature search strategy applied keywords, BOOLEAN search operators, and eligibility criteria on PubMed, Medline, and Google Scholar databases. Cormack's (2000) critique framework was chosen to methodologically appraise the mixed-method studies to evaluate the quality, validity and rigour.!!Results!!The search decisions were displayed in a PRISMA flowchart to evidence the process to identify the found articles comprised of two surveys, two semi-structured interviews and one case study. The findings identified common and reoccurring themes of personal protective equipment, mental wellbeing, accommodation and travel, assessments and learning, and transitioning to registration.!!Conclusion!!The literature suggests that students felt positive impacts of the pandemic, such as being prepared for registration. However, negative effects included the fear of contracting the virus, anxieties of working with ill patients, impracticalities of accommodation and travel during clinical placement, and the adaption to online learning.!!Implications for practice!!Clinical staff and universities need to work together to ensure students are mentally and physically supported during the pandemic. Regular meetings and agreed channels of communication with students will allow any issues to be brought to attention and addressed. In addition, employers should recognise that newly qualified radiographers will need extra support. | 1887 | 1078-8174 | Radiography (London, England : 1995) | Amsterdam : Elsevier B.V. | ||
| 1128 | 114797 | COVID19(2023년) | wellbeing | Term | wellbeing | abstract | 33227 | https://doi.org/10.1016/j.radi.2021.09.009 | COVID-19: A literature review of the impact on diagnostic radiography students | D. Astirbadi|||P. Lockwood | 202205 | Review article | Sciencedirect | Abstract!!Introduction!!COVID-19 is a highly contagious viral disease declared a global pandemic in March 2020. Throughout the pandemic, radiography students have been working in hospitals on the frontline. The review aimed to search for evidence of the impact COVID-19 has had on diagnostic radiography students and consider whether additional support and learning needs to be implemented.!!Methods!!A literature search strategy applied keywords, BOOLEAN search operators, and eligibility criteria on PubMed, Medline, and Google Scholar databases. Cormack's (2000) critique framework was chosen to methodologically appraise the mixed-method studies to evaluate the quality, validity and rigour.!!Results!!The search decisions were displayed in a PRISMA flowchart to evidence the process to identify the found articles comprised of two surveys, two semi-structured interviews and one case study. The findings identified common and reoccurring themes of personal protective equipment, mental wellbeing, accommodation and travel, assessments and learning, and transitioning to registration.!!Conclusion!!The literature suggests that students felt positive impacts of the pandemic, such as being prepared for registration. However, negative effects included the fear of contracting the virus, anxieties of working with ill patients, impracticalities of accommodation and travel during clinical placement, and the adaption to online learning.!!Implications for practice!!Clinical staff and universities need to work together to ensure students are mentally and physically supported during the pandemic. Regular meetings and agreed channels of communication with students will allow any issues to be brought to attention and addressed. In addition, employers should recognise that newly qualified radiographers will need extra support. | 1887 | 1078-8174 | Radiography (London, England : 1995) | Amsterdam : Elsevier B.V. | |||
| 1096 | 114797 | COVID19(2023년) | diagnostic | Term | diagnostic | title,abstract | 진단상(診斷上)의 | 33227 | https://doi.org/10.1016/j.radi.2021.09.009 | COVID-19: A literature review of the impact on diagnostic radiography students | D. Astirbadi|||P. Lockwood | 202205 | Review article | Sciencedirect | Abstract!!Introduction!!COVID-19 is a highly contagious viral disease declared a global pandemic in March 2020. Throughout the pandemic, radiography students have been working in hospitals on the frontline. The review aimed to search for evidence of the impact COVID-19 has had on diagnostic radiography students and consider whether additional support and learning needs to be implemented.!!Methods!!A literature search strategy applied keywords, BOOLEAN search operators, and eligibility criteria on PubMed, Medline, and Google Scholar databases. Cormack's (2000) critique framework was chosen to methodologically appraise the mixed-method studies to evaluate the quality, validity and rigour.!!Results!!The search decisions were displayed in a PRISMA flowchart to evidence the process to identify the found articles comprised of two surveys, two semi-structured interviews and one case study. The findings identified common and reoccurring themes of personal protective equipment, mental wellbeing, accommodation and travel, assessments and learning, and transitioning to registration.!!Conclusion!!The literature suggests that students felt positive impacts of the pandemic, such as being prepared for registration. However, negative effects included the fear of contracting the virus, anxieties of working with ill patients, impracticalities of accommodation and travel during clinical placement, and the adaption to online learning.!!Implications for practice!!Clinical staff and universities need to work together to ensure students are mentally and physically supported during the pandemic. Regular meetings and agreed channels of communication with students will allow any issues to be brought to attention and addressed. In addition, employers should recognise that newly qualified radiographers will need extra support. | 1887 | 1078-8174 | Radiography (London, England : 1995) | Amsterdam : Elsevier B.V. | ||
| 1115 | 114797 | COVID19(2023년) | physically | Term | physically | abstract | 물리적으로 | 33227 | https://doi.org/10.1016/j.radi.2021.09.009 | COVID-19: A literature review of the impact on diagnostic radiography students | D. Astirbadi|||P. Lockwood | 202205 | Review article | Sciencedirect | Abstract!!Introduction!!COVID-19 is a highly contagious viral disease declared a global pandemic in March 2020. Throughout the pandemic, radiography students have been working in hospitals on the frontline. The review aimed to search for evidence of the impact COVID-19 has had on diagnostic radiography students and consider whether additional support and learning needs to be implemented.!!Methods!!A literature search strategy applied keywords, BOOLEAN search operators, and eligibility criteria on PubMed, Medline, and Google Scholar databases. Cormack's (2000) critique framework was chosen to methodologically appraise the mixed-method studies to evaluate the quality, validity and rigour.!!Results!!The search decisions were displayed in a PRISMA flowchart to evidence the process to identify the found articles comprised of two surveys, two semi-structured interviews and one case study. The findings identified common and reoccurring themes of personal protective equipment, mental wellbeing, accommodation and travel, assessments and learning, and transitioning to registration.!!Conclusion!!The literature suggests that students felt positive impacts of the pandemic, such as being prepared for registration. However, negative effects included the fear of contracting the virus, anxieties of working with ill patients, impracticalities of accommodation and travel during clinical placement, and the adaption to online learning.!!Implications for practice!!Clinical staff and universities need to work together to ensure students are mentally and physically supported during the pandemic. Regular meetings and agreed channels of communication with students will allow any issues to be brought to attention and addressed. In addition, employers should recognise that newly qualified radiographers will need extra support. | 1887 | 1078-8174 | Radiography (London, England : 1995) | Amsterdam : Elsevier B.V. | ||
| 1170 | 114797 | COVID19(2023년) | Fighting | Term | Fighting | title | 37452 | https://doi.org/10.1038/s41592-022-01448-9 | Fighting SARS-CoV-2 with structural biology methods | 202204 | Comments & Opinion | Nature | 888 | 1548-7091 | Nature methods | New York, NY : Nature Pub. Group | |||||
| 3086 | 114797 | COVID19(2023년) | Vaccines. | Term | vaccines | author | 백신 | 239468 | https://doi.org/10.5694/mja2.51479 | Effectiveness of COVID-19 vaccines: findings from real-world studies | David A Henry|||Mark A Jones|||Paulina Stehlik|||Paul P Glasziou | 202205 | pubmed | None | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/9115044/ | 268 | 0025-729X | The Medical journal of Australia | Pyrmont, NSW : Australasian Medical Publishing Co. | ||
| 3087 | 114797 | COVID19(2023년) | COVID-19 | Disease | COVID-19 | title | 코로나-19 | 239560 | https://doi.org/10.1016/S1473-3099(22)00210-9 | Interplay of infection and vaccination in long-term protection from COVID-19 | Hyon-Xhi Tan|||Jennifer A Juno | 202206 | Comment | pubmed | None | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/8971275/ | 36 | 1473-3099 | The Lancet. Infectious Diseases | New York, NY : Elsevier Science ; The Lancet Pub. Group | 10.23600 |
| 11929 | 114797 | COVID19(2023년) | LDLR | Gene | LDLR | abstract | 16933 | https://doi.org/10.1210/endrev/bnab035 | The Multifaceted Biology of PCSK9 | Nabil G Seidah|||Annik Prat | 202205 | Review | PMC | {{{ Abstract }}} !! This article reviews the discovery of PCSK9, its structure-function characteristics, and its presently known and proposed novel biological functions. The major critical function of PCSK9 deduced from human and mouse studies, as well as cellular and structural analyses, is its role in increasing the levels of circulating low-density lipoprotein (LDL)-cholesterol (LDLc), via its ability to enhance the sorting and escort of the cell surface LDL receptor (LDLR) to lysosomes. This implicates the binding of the catalytic domain of PCSK9 to the EGF-A domain of the LDLR. This also requires the presence of the C-terminal Cys/His-rich domain, its binding to the secreted cytosolic cyclase associated protein 1, and possibly another membrane-bound protein X. Curiously, in PCSK9-deficient mice, an alternative to the downregulation of the surface levels of the LDLR by PCSK9 is taking place in the liver of female mice in a 17β-estradiol-dependent manner by still an unknown mechanism. Recent studies have extended our understanding of the biological functions of PCSK9, namely its implication in septic shock, vascular inflammation, viral infections (Dengue; SARS-CoV-2) or immune checkpoint modulation in cancer via the regulation of the cell surface levels of the T-cell receptor and MHC-I, which govern the antitumoral activity of CD8+ T cells. Because PCSK9 inhibition may be advantageous in these processes, the availability of injectable safe PCSK9 inhibitors that reduces by 50% to 60% LDLc above the effect of statins is highly valuable. Indeed, injectable PCSK9 monoclonal antibody or small interfering RNA could be added to current immunotherapies in cancer/metastasis. !!{{ Keywords: }} cancer/metastases; hypercholesterolemia; major histocompatibility complex I; sepsis; β-cells. | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/9113161/ | 1700 | 0163-769X | Endocrine reviews | New York : Oxford University Press. | ||
| 11927 | 114797 | COVID19(2023년) | immunotherapy | Treatment | immunotherapy | abstract | 면역요법 | 16933 | https://doi.org/10.1210/endrev/bnab035 | The Multifaceted Biology of PCSK9 | Nabil G Seidah|||Annik Prat | 202205 | Review | PMC | {{{ Abstract }}} !! This article reviews the discovery of PCSK9, its structure-function characteristics, and its presently known and proposed novel biological functions. The major critical function of PCSK9 deduced from human and mouse studies, as well as cellular and structural analyses, is its role in increasing the levels of circulating low-density lipoprotein (LDL)-cholesterol (LDLc), via its ability to enhance the sorting and escort of the cell surface LDL receptor (LDLR) to lysosomes. This implicates the binding of the catalytic domain of PCSK9 to the EGF-A domain of the LDLR. This also requires the presence of the C-terminal Cys/His-rich domain, its binding to the secreted cytosolic cyclase associated protein 1, and possibly another membrane-bound protein X. Curiously, in PCSK9-deficient mice, an alternative to the downregulation of the surface levels of the LDLR by PCSK9 is taking place in the liver of female mice in a 17β-estradiol-dependent manner by still an unknown mechanism. Recent studies have extended our understanding of the biological functions of PCSK9, namely its implication in septic shock, vascular inflammation, viral infections (Dengue; SARS-CoV-2) or immune checkpoint modulation in cancer via the regulation of the cell surface levels of the T-cell receptor and MHC-I, which govern the antitumoral activity of CD8+ T cells. Because PCSK9 inhibition may be advantageous in these processes, the availability of injectable safe PCSK9 inhibitors that reduces by 50% to 60% LDLc above the effect of statins is highly valuable. Indeed, injectable PCSK9 monoclonal antibody or small interfering RNA could be added to current immunotherapies in cancer/metastasis. !!{{ Keywords: }} cancer/metastases; hypercholesterolemia; major histocompatibility complex I; sepsis; β-cells. | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/9113161/ | 1700 | 0163-769X | Endocrine reviews | New York : Oxford University Press. | |
| 11928 | 114797 | COVID19(2023년) | LDL | Protein | LDL | abstract | 저밀도 지질단백질 | 16933 | https://doi.org/10.1210/endrev/bnab035 | The Multifaceted Biology of PCSK9 | Nabil G Seidah|||Annik Prat | 202205 | Review | PMC | {{{ Abstract }}} !! This article reviews the discovery of PCSK9, its structure-function characteristics, and its presently known and proposed novel biological functions. The major critical function of PCSK9 deduced from human and mouse studies, as well as cellular and structural analyses, is its role in increasing the levels of circulating low-density lipoprotein (LDL)-cholesterol (LDLc), via its ability to enhance the sorting and escort of the cell surface LDL receptor (LDLR) to lysosomes. This implicates the binding of the catalytic domain of PCSK9 to the EGF-A domain of the LDLR. This also requires the presence of the C-terminal Cys/His-rich domain, its binding to the secreted cytosolic cyclase associated protein 1, and possibly another membrane-bound protein X. Curiously, in PCSK9-deficient mice, an alternative to the downregulation of the surface levels of the LDLR by PCSK9 is taking place in the liver of female mice in a 17β-estradiol-dependent manner by still an unknown mechanism. Recent studies have extended our understanding of the biological functions of PCSK9, namely its implication in septic shock, vascular inflammation, viral infections (Dengue; SARS-CoV-2) or immune checkpoint modulation in cancer via the regulation of the cell surface levels of the T-cell receptor and MHC-I, which govern the antitumoral activity of CD8+ T cells. Because PCSK9 inhibition may be advantageous in these processes, the availability of injectable safe PCSK9 inhibitors that reduces by 50% to 60% LDLc above the effect of statins is highly valuable. Indeed, injectable PCSK9 monoclonal antibody or small interfering RNA could be added to current immunotherapies in cancer/metastasis. !!{{ Keywords: }} cancer/metastases; hypercholesterolemia; major histocompatibility complex I; sepsis; β-cells. | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/9113161/ | 1700 | 0163-769X | Endocrine reviews | New York : Oxford University Press. | |
| 4141 | 114797 | COVID19(2023년) | female | Term | female | abstract | 여성 | 245306 | https://doi.org/10.1007/s00431-022-04600-x | Prevalence and clinical presentation of long COVID in children: a systematic review | Roberta Pellegrino|||Elena Chiappini|||Amelia Licari|||Luisa Galli|||Gian Luigi Marseglia | 202212 | Review | pubmed | A systematic literature review was conducted up to 15th February 2022 to summarize long COVID evidence and to assess prevalence and clinical presentation in children and adolescents. Articles reporting long COVID prevalence and symptoms based on original data in the paediatric population were included. Case series quality was assessed through the JBI Critical Appraisal Checklist. For observational studies, adherence to STROBE checklist was evaluated. Twenty-two articles were included: 19 observational studies (12 cohort/7 cross-sectional) and 3 case series. Nine studies provided a control group. We found a high variability in terms of prevalence (1.6-70%). The most frequently reported symptoms were fatigue (2-87%), headache (3.5-80%), arthro-myalgias (5.4-66%), chest tightness or pain (1.4-51%), and dyspnoea (2-57.1%). Five studies reported limitations in daily function due to long COVID. Alterations at brain imaging were described in one study, transient electrocardiographic abnormalities were described in a minority of children, while most authors did not evidence long-term pulmonary sequelae. Older age, female sex, and previous long-term pathological conditions were more frequently associated with persistent symptoms. !!{{ Conclusion: }} Long COVID evidence in children is limited, heterogeneous, and based on low-quality studies. The lockdown consequences are difficult to distinguish from long COVID symptoms. High-quality studies are required: WHO definition of long COVID should be used, controlled clinical studies should be encouraged, and the impact of new variants on long COVID prevalence should be investigated to ensure an objective analysis of long COVID characteristics in children and a proper allocation of healthcare system resources. !!{{ What is known: }} ? Children rarely develop a severe respiratory disease in the acute phase of COVID-19. ? A limited number of patients develop a multisystem inflammatory condition that can lead to multiorgan failure and shock. !!{{ What is new: }} ? Persistent symptoms after SARS-CoV-2 infection are reported in children and limitations in daily function due to long COVID symptoms affect school attendance. ? Functional complaints of post-acute COVID are difficult to be distinguished from those due to social restrictions. | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/9476461/ | 373 | 0340-6199 | European journal of pediatrics | Berlin : Springer Verlag. | |
| 11945 | 114797 | COVID19(2023년) | reduce | Action | reduce | abstract | 16933 | https://doi.org/10.1210/endrev/bnab035 | The Multifaceted Biology of PCSK9 | Nabil G Seidah|||Annik Prat | 202205 | Review | PMC | {{{ Abstract }}} !! This article reviews the discovery of PCSK9, its structure-function characteristics, and its presently known and proposed novel biological functions. The major critical function of PCSK9 deduced from human and mouse studies, as well as cellular and structural analyses, is its role in increasing the levels of circulating low-density lipoprotein (LDL)-cholesterol (LDLc), via its ability to enhance the sorting and escort of the cell surface LDL receptor (LDLR) to lysosomes. This implicates the binding of the catalytic domain of PCSK9 to the EGF-A domain of the LDLR. This also requires the presence of the C-terminal Cys/His-rich domain, its binding to the secreted cytosolic cyclase associated protein 1, and possibly another membrane-bound protein X. Curiously, in PCSK9-deficient mice, an alternative to the downregulation of the surface levels of the LDLR by PCSK9 is taking place in the liver of female mice in a 17β-estradiol-dependent manner by still an unknown mechanism. Recent studies have extended our understanding of the biological functions of PCSK9, namely its implication in septic shock, vascular inflammation, viral infections (Dengue; SARS-CoV-2) or immune checkpoint modulation in cancer via the regulation of the cell surface levels of the T-cell receptor and MHC-I, which govern the antitumoral activity of CD8+ T cells. Because PCSK9 inhibition may be advantageous in these processes, the availability of injectable safe PCSK9 inhibitors that reduces by 50% to 60% LDLc above the effect of statins is highly valuable. Indeed, injectable PCSK9 monoclonal antibody or small interfering RNA could be added to current immunotherapies in cancer/metastasis. !!{{ Keywords: }} cancer/metastases; hypercholesterolemia; major histocompatibility complex I; sepsis; β-cells. | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/9113161/ | 1700 | 0163-769X | Endocrine reviews | New York : Oxford University Press. | ||
| 11949 | 114797 | COVID19(2023년) | SARS-CoV-2 | Virus | SARS-CoV-2 | abstract | 제2형 중증급성호흡기증후군 코로나바이러스 | 16933 | https://doi.org/10.1210/endrev/bnab035 | The Multifaceted Biology of PCSK9 | Nabil G Seidah|||Annik Prat | 202205 | Review | PMC | {{{ Abstract }}} !! This article reviews the discovery of PCSK9, its structure-function characteristics, and its presently known and proposed novel biological functions. The major critical function of PCSK9 deduced from human and mouse studies, as well as cellular and structural analyses, is its role in increasing the levels of circulating low-density lipoprotein (LDL)-cholesterol (LDLc), via its ability to enhance the sorting and escort of the cell surface LDL receptor (LDLR) to lysosomes. This implicates the binding of the catalytic domain of PCSK9 to the EGF-A domain of the LDLR. This also requires the presence of the C-terminal Cys/His-rich domain, its binding to the secreted cytosolic cyclase associated protein 1, and possibly another membrane-bound protein X. Curiously, in PCSK9-deficient mice, an alternative to the downregulation of the surface levels of the LDLR by PCSK9 is taking place in the liver of female mice in a 17β-estradiol-dependent manner by still an unknown mechanism. Recent studies have extended our understanding of the biological functions of PCSK9, namely its implication in septic shock, vascular inflammation, viral infections (Dengue; SARS-CoV-2) or immune checkpoint modulation in cancer via the regulation of the cell surface levels of the T-cell receptor and MHC-I, which govern the antitumoral activity of CD8+ T cells. Because PCSK9 inhibition may be advantageous in these processes, the availability of injectable safe PCSK9 inhibitors that reduces by 50% to 60% LDLc above the effect of statins is highly valuable. Indeed, injectable PCSK9 monoclonal antibody or small interfering RNA could be added to current immunotherapies in cancer/metastasis. !!{{ Keywords: }} cancer/metastases; hypercholesterolemia; major histocompatibility complex I; sepsis; β-cells. | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/9113161/ | 1700 | 0163-769X | Endocrine reviews | New York : Oxford University Press. | |
| 2527 | 114797 | COVID19(2023년) | COVID-19 vaccine | Drug | COVID-19 vaccine | title | 코로나19 백신 | 236862 | https://doi.org/10.1038/d41587-022-00001-5 | COVID-19 vaccine makers chase variant-ready vaccines | Cormac Sheridan | 202202 | pubmed | None | https://pubmed.ncbi.nlm.nih.gov/35046613/ | 941 | 1087-0156 | Nature biotechnology | New York Ny : Nature America Publishing. | ||
| 2682 | 114797 | COVID19(2023년) | COVID-19 | Disease | COVID-19 | title | 코로나-19 | 237662 | https://doi.org/10.1177/10398562211060716 | What should psychiatrists advise their patients regarding COVID-19 protective measures and vaccination? | Jeffrey Cl Looi|||Stephen Allison|||Tarun Bastiampillai|||Paul A Maguire | 202206 | pubmed | None | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/8832128/ | 1838 | 1039-8562 | Australasian psychiatry : bulletin of Royal Austra | London : Sage. | ||
| 11956 | 114797 | COVID19(2023년) | viral infection | Action | viral infection | abstract | 바이러스 감염 | 16933 | https://doi.org/10.1210/endrev/bnab035 | The Multifaceted Biology of PCSK9 | Nabil G Seidah|||Annik Prat | 202205 | Review | PMC | {{{ Abstract }}} !! This article reviews the discovery of PCSK9, its structure-function characteristics, and its presently known and proposed novel biological functions. The major critical function of PCSK9 deduced from human and mouse studies, as well as cellular and structural analyses, is its role in increasing the levels of circulating low-density lipoprotein (LDL)-cholesterol (LDLc), via its ability to enhance the sorting and escort of the cell surface LDL receptor (LDLR) to lysosomes. This implicates the binding of the catalytic domain of PCSK9 to the EGF-A domain of the LDLR. This also requires the presence of the C-terminal Cys/His-rich domain, its binding to the secreted cytosolic cyclase associated protein 1, and possibly another membrane-bound protein X. Curiously, in PCSK9-deficient mice, an alternative to the downregulation of the surface levels of the LDLR by PCSK9 is taking place in the liver of female mice in a 17β-estradiol-dependent manner by still an unknown mechanism. Recent studies have extended our understanding of the biological functions of PCSK9, namely its implication in septic shock, vascular inflammation, viral infections (Dengue; SARS-CoV-2) or immune checkpoint modulation in cancer via the regulation of the cell surface levels of the T-cell receptor and MHC-I, which govern the antitumoral activity of CD8+ T cells. Because PCSK9 inhibition may be advantageous in these processes, the availability of injectable safe PCSK9 inhibitors that reduces by 50% to 60% LDLc above the effect of statins is highly valuable. Indeed, injectable PCSK9 monoclonal antibody or small interfering RNA could be added to current immunotherapies in cancer/metastasis. !!{{ Keywords: }} cancer/metastases; hypercholesterolemia; major histocompatibility complex I; sepsis; β-cells. | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/9113161/ | 1700 | 0163-769X | Endocrine reviews | New York : Oxford University Press. | |
| 3509 | 114797 | COVID19(2023년) | COVID-19 | Disease | COVID-19 | title | 코로나-19 | 241608 | https://doi.org/10.5935/1518-0557.20220018 | Statement - COVID-19 Vaccination - Male and Female fertility, treatments to get pregnant, pregnancy | 202204 | Editorial | pubmed | None | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/9118963/ | 3408 | JBRA Assisted Reproduction | ||||
| 3510 | 114797 | COVID19(2023년) | Female fertility | Term | female fertility | title | 241608 | https://doi.org/10.5935/1518-0557.20220018 | Statement - COVID-19 Vaccination - Male and Female fertility, treatments to get pregnant, pregnancy | 202204 | Editorial | pubmed | None | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/9118963/ | 3408 | JBRA Assisted Reproduction | |||||
| 3511 | 114797 | COVID19(2023년) | pregnancy | Term | pregnancy | title | 임신 | 241608 | https://doi.org/10.5935/1518-0557.20220018 | Statement - COVID-19 Vaccination - Male and Female fertility, treatments to get pregnant, pregnancy | 202204 | Editorial | pubmed | None | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/9118963/ | 3408 | JBRA Assisted Reproduction | ||||
| 3074 | 114797 | COVID19(2023년) | COVID-19 | Disease | COVID-19 | author,title | 코로나-19 | 239238 | https://doi.org/10.1002/ppul.25901 | Developing artificial intelligence technology for pediatric pulmonology: Lessons from COVID-19 | Gustavo Nino|||Marius G Linguraru | 202207 | pubmed | None | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/9088653/ | 1164 | 8755-6863 | Pediatric pulmonology | Hoboken, NJ : Wiley-Liss. | ||
| 3541 | 114797 | COVID19(2023년) | COVID-19 pandemic | Term | COVID-19 pandemic | title | COVID-19 팬데믹 | 242668 | https://doi.org/10.1016/j.pulmoe.2022.04.012 | Impact of the COVID-19 pandemic on in-hospital diagnosis of tuberculosis in non-HIV patients | M Martins|||L Carvalho|||T Carvalho|||I Gomes | 202211 | pubmed | None | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/9091262/ | 1601 | 2531-0429 | Pulmonology | [Barcelona] : Elsevier Espa?a | ||
| 3354 | 114797 | COVID19(2023년) | Reply | Term | Reply | title | 241078 | https://doi.org/10.1016/j.medine.2022.04.005 | Reply to Pulmonary toxicity by oxygen and COVID-19 | A Belenguer-Muncharaz|||H Hern?ndez-Garc?s | 202206 | Comment | pubmed | None | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/9042942/ | 907 | 2173-5727 | Medicina intensiva | English ed. [Barcelona?] : Elsevier Espan?a | ||
| 3353 | 114797 | COVID19(2023년) | oxygen | Drug | oxygen | title | 산소 | 241078 | https://doi.org/10.1016/j.medine.2022.04.005 | Reply to Pulmonary toxicity by oxygen and COVID-19 | A Belenguer-Muncharaz|||H Hern?ndez-Garc?s | 202206 | Comment | pubmed | None | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/9042942/ | 907 | 2173-5727 | Medicina intensiva | English ed. [Barcelona?] : Elsevier Espan?a | |
| 4117 | 114797 | COVID19(2023년) | article | Term | Article | abstract | 245306 | https://doi.org/10.1007/s00431-022-04600-x | Prevalence and clinical presentation of long COVID in children: a systematic review | Roberta Pellegrino|||Elena Chiappini|||Amelia Licari|||Luisa Galli|||Gian Luigi Marseglia | 202212 | Review | pubmed | A systematic literature review was conducted up to 15th February 2022 to summarize long COVID evidence and to assess prevalence and clinical presentation in children and adolescents. Articles reporting long COVID prevalence and symptoms based on original data in the paediatric population were included. Case series quality was assessed through the JBI Critical Appraisal Checklist. For observational studies, adherence to STROBE checklist was evaluated. Twenty-two articles were included: 19 observational studies (12 cohort/7 cross-sectional) and 3 case series. Nine studies provided a control group. We found a high variability in terms of prevalence (1.6-70%). The most frequently reported symptoms were fatigue (2-87%), headache (3.5-80%), arthro-myalgias (5.4-66%), chest tightness or pain (1.4-51%), and dyspnoea (2-57.1%). Five studies reported limitations in daily function due to long COVID. Alterations at brain imaging were described in one study, transient electrocardiographic abnormalities were described in a minority of children, while most authors did not evidence long-term pulmonary sequelae. Older age, female sex, and previous long-term pathological conditions were more frequently associated with persistent symptoms. !!{{ Conclusion: }} Long COVID evidence in children is limited, heterogeneous, and based on low-quality studies. The lockdown consequences are difficult to distinguish from long COVID symptoms. High-quality studies are required: WHO definition of long COVID should be used, controlled clinical studies should be encouraged, and the impact of new variants on long COVID prevalence should be investigated to ensure an objective analysis of long COVID characteristics in children and a proper allocation of healthcare system resources. !!{{ What is known: }} ? Children rarely develop a severe respiratory disease in the acute phase of COVID-19. ? A limited number of patients develop a multisystem inflammatory condition that can lead to multiorgan failure and shock. !!{{ What is new: }} ? Persistent symptoms after SARS-CoV-2 infection are reported in children and limitations in daily function due to long COVID symptoms affect school attendance. ? Functional complaints of post-acute COVID are difficult to be distinguished from those due to social restrictions. | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/9476461/ | 373 | 0340-6199 | European journal of pediatrics | Berlin : Springer Verlag. | ||
| 5320 | 114797 | COVID19(2023년) | within-host | Term | within-host | abstract | 248495 | https://doi.org/10.1016/j.jtbi.2022.111403 | Relationship between the inclusion/exclusion criteria and sample size in randomized controlled trials for SARS-CoV-2 entry inhibitors | Daiki Tatematsu|||Marwa Akao|||Hyeongki Park|||Shingo Iwami|||Keisuke Ejima|||Shoya Iwanami | 202303 | pubmed | The coronavirus disease 2019 (COVID-19) pandemic that has been ongoing since 2019 is still ongoing and how to control it is one of the international issues to be addressed. Antiviral drugs that reduce the viral load in terms of reducing the risk of secondary infection are important. For the general control of emerging infectious diseases, establishing an efficient method to evaluate candidate therapeutic agents will lead to a rapid response. We evaluated clinical trial designs for viral entry inhibitors that have the potential to be effective pre-exposure prophylactic drugs in addition to reducing viral load after infection. We used a previously developed simulation of clinical trials based on a mathematical model of within-host viral infection dynamics to evaluate sample sizes in clinical trials of viral entry inhibitors against COVID-19. We assumed four measures as outcomes, namely change in log10-transformed viral load from symptom onset, PCR positive ratio, log10-transformed viral load, and cumulative viral load, and then sample sizes were calculated for drugs with 99 % and 95 % antiviral efficacy. Consistent with previous results, we found that sample sizes could be dramatically reduced for all outcomes used in an analysis by adopting inclusion/exclusion criteria such that only patients in the early post-infection period would be included in a clinical trial. A comparison of sample sizes across outcomes demonstrated an optimal measurement schedule associated with the nature of the outcome measured for the evaluation of drug efficacy. In particular, the sample sizes calculated from the change in viral load and from viral load tended to be small when measurements were taken at earlier time points after treatment initiation. For the cumulative viral load, the sample size was lower than that from the other outcomes when the stricter inclusion/exclusion criteria to include patients whose time since onset is earlier than 2 days was used. We concluded that the design of efficient clinical trials should consider the inclusion/exclusion criteria and measurement schedules, as well as outcome selection based on sample size, personnel and budget needed to conduct the trial, and the importance of the outcome regarding the medical and societal requirements. This study provides insights into clinical trial design for a variety of situations, especially addressing infectious disease prevalence and feasible trial sizes. This manuscript was submitted as part of a theme issue on Modelling COVID-19 and Preparedness for Future Pandemics. | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/9794526/ | 1779 | 0022-5193 | Journal of theoretical biology | Amsterdam : Elsevier. | |||
| 9199 | 114797 | COVID19(2023년) | COVID-19 phenotype | Term | COVID-19 phenotype | abstract | 243067 | https://doi.org/10.1089/thy.2022.0243 | COVID-19 and Thyroid Function: A Bi-Directional Two-Sample Mendelian Randomization Study | Gloria Hoi-Yee Li|||Ching-Man Tang|||Ching-Lung Cheung | 202209 | pubmed | Background: Thyroid dysfunction has been observed among some patients with coronavirus disease (COVID-19). It is unclear whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (or its severity) leads to the development of thyroid dysfunction, or vice versa. In this study, we examined the bi-directional causal relationship between host genetic liability to three COVID-19 phenotypes (including SARS-CoV-2 infection, hospitalized and severe COVID-19) and three thyroid dysfunction traits (including hyperthyroidism, hypothyroidism, and autoimmune thyroid disease [AITD]) and three continuous traits of thyroid hormones (including thyrotropin [TSH] and free thyroxine [fT4] within reference range, and TSH in full range). Methods: Summary statistics from the largest available meta-analyses of human genome-wide association studies were retrieved for the following variables: SARS-CoV-2 infection ( n = 1,348,701), COVID-19 hospitalization ( n = 1,557,411), severe COVID-19 ( n = 1,059,456), hyperthyroidism ( n = 51,823), hypothyroidism ( n = 53,423), AITD ( n = 755,406), TSH within reference range ( n = 54,288), fT4 within reference range ( n = 49,269), and TSH in full range ( n = 119,715). Using a two-sample Mendelian randomization (MR) approach, the inverse-variance weighted (IVW) method was adopted as the main MR analysis. Weighted median, contamination mixture, MR-Egger, and MR pleiotropy residual sum and outlier (MR-PRESSO) methods were applied as sensitivity analyses. Results: Host genetic susceptibility to SARS-CoV-2 infection was causally associated with hypothyroidism in the main IVW analysis (per doubling in prevalence of SARS-CoV-2 infection, odds ratio [OR] = 1.335; 95% confidence interval [CI]: 1.167-1.526; p = 2.4 × 10^{-5}, surpassing the Bonferroni multiple-testing threshold). Similar causal estimates were observed in the sensitivity analyses (weighted median: OR = 1.296; CI: 1.066-1.575; p = 9 × 10^{-3}; contamination mixture: OR = 1.356; CI: 1.095-1.818; p = 0.013; MR-Egger: OR = 1.712; CI: 1.202-2.439; p = 2.92 × 10^{-3}, and MR-PRESSO: OR = 1.335; CI: 1.156-1.542; p = 5.73 × 10^{-4}). Host genetic liability to hospitalized or severe COVID-19 was not associated with thyroid dysfunction or thyroid hormone levels. In the reverse direction, there was no evidence to suggest that genetic predisposition to thyroid dysfunction or genetically determined thyroid hormone levels altered the risk of the COVID-19 outcomes. Conclusions: This bi-directional MR study supports that host response to SARS-CoV-2 viral infection plays a role in the causal association with increased risk of hypothyroidism. Long-term follow-up studies are needed to confirm the expected increased hypothyroidism risk. | https://pubmed.ncbi.nlm.nih.gov/35734897/ | 4630 | 1050-7256 | Thyroid : official journal of the American Thyroid Association | New York, NY : Mary Ann Liebert Publishers,. | |||
| 9200 | 114797 | COVID19(2023년) | disease | Disease | disease | abstract | 질병 | 243067 | https://doi.org/10.1089/thy.2022.0243 | COVID-19 and Thyroid Function: A Bi-Directional Two-Sample Mendelian Randomization Study | Gloria Hoi-Yee Li|||Ching-Man Tang|||Ching-Lung Cheung | 202209 | pubmed | Background: Thyroid dysfunction has been observed among some patients with coronavirus disease (COVID-19). It is unclear whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (or its severity) leads to the development of thyroid dysfunction, or vice versa. In this study, we examined the bi-directional causal relationship between host genetic liability to three COVID-19 phenotypes (including SARS-CoV-2 infection, hospitalized and severe COVID-19) and three thyroid dysfunction traits (including hyperthyroidism, hypothyroidism, and autoimmune thyroid disease [AITD]) and three continuous traits of thyroid hormones (including thyrotropin [TSH] and free thyroxine [fT4] within reference range, and TSH in full range). Methods: Summary statistics from the largest available meta-analyses of human genome-wide association studies were retrieved for the following variables: SARS-CoV-2 infection ( n = 1,348,701), COVID-19 hospitalization ( n = 1,557,411), severe COVID-19 ( n = 1,059,456), hyperthyroidism ( n = 51,823), hypothyroidism ( n = 53,423), AITD ( n = 755,406), TSH within reference range ( n = 54,288), fT4 within reference range ( n = 49,269), and TSH in full range ( n = 119,715). Using a two-sample Mendelian randomization (MR) approach, the inverse-variance weighted (IVW) method was adopted as the main MR analysis. Weighted median, contamination mixture, MR-Egger, and MR pleiotropy residual sum and outlier (MR-PRESSO) methods were applied as sensitivity analyses. Results: Host genetic susceptibility to SARS-CoV-2 infection was causally associated with hypothyroidism in the main IVW analysis (per doubling in prevalence of SARS-CoV-2 infection, odds ratio [OR] = 1.335; 95% confidence interval [CI]: 1.167-1.526; p = 2.4 × 10^{-5}, surpassing the Bonferroni multiple-testing threshold). Similar causal estimates were observed in the sensitivity analyses (weighted median: OR = 1.296; CI: 1.066-1.575; p = 9 × 10^{-3}; contamination mixture: OR = 1.356; CI: 1.095-1.818; p = 0.013; MR-Egger: OR = 1.712; CI: 1.202-2.439; p = 2.92 × 10^{-3}, and MR-PRESSO: OR = 1.335; CI: 1.156-1.542; p = 5.73 × 10^{-4}). Host genetic liability to hospitalized or severe COVID-19 was not associated with thyroid dysfunction or thyroid hormone levels. In the reverse direction, there was no evidence to suggest that genetic predisposition to thyroid dysfunction or genetically determined thyroid hormone levels altered the risk of the COVID-19 outcomes. Conclusions: This bi-directional MR study supports that host response to SARS-CoV-2 viral infection plays a role in the causal association with increased risk of hypothyroidism. Long-term follow-up studies are needed to confirm the expected increased hypothyroidism risk. | https://pubmed.ncbi.nlm.nih.gov/35734897/ | 4630 | 1050-7256 | Thyroid : official journal of the American Thyroid Association | New York, NY : Mary Ann Liebert Publishers,. | ||
| 8537 | 114797 | COVID19(2023년) | retrospective cohort study | Term | retrospective cohort study | abstract | 239865 | https://doi.org/10.1016/j.ajogmf.2022.100637 | Safety of third SARS-CoV-2 vaccine (booster dose) during pregnancy | Aharon Dick|||Joshua I Rosenbloom|||Gilad Karavani|||Einat Gutman-Ido|||Naama Lessans|||Henry H Chill | 202207 | pubmed | {{ Background: }} COVID-19 during pregnancy is associated with adverse outcomes for both the mother and fetus. SARS-CoV-2 vaccination has significantly reduced the risk for symptomatic disease. Several studies have reported on the safety of SARS-CoV-2 vaccination during pregnancy, with no adverse effects on the obstetrical outcomes. However, data regarding the obstetrical outcomes following a booster dose of the SARS CoV-2 vaccination during pregnancy have not yet to be published. !!{{ Objective: }} This study aimed to examine the association between the booster dose of the SARS CoV-2 vaccination during pregnancy and obstetrical outcomes. !!{{ Study design: }} This was a retrospective cohort study of women who delivered between July and October 2021 at a large tertiary medical center. We compared women who received the booster vaccination dose during pregnancy with women who were not vaccinated and with those who only received 2 vaccination doses. Primary outcomes were the incidence of preterm labor and of small for gestational age neonates. Secondary outcomes were other maternal and neonatal complications. A secondary analysis investigating the association between the time from vaccination to delivery and the outcomes was also performed. Multivariable logistic regression models were used to adjust for potential confounders. !!{{ Results: }} There were 6507 women who met the inclusion criteria: 294 women received 3 doses of the vaccination, 2845 women received only 2 doses, and 3368 were unvaccinated. Patients receiving 3 doses of the vaccine were older and more likely to smoke than unvaccinated patients. No differences were noted among the triple-vaccinated, twice-vaccinated, and unvaccinated groups with regards to preterm birth and the incidence of small for gestational age neonates. Regarding the secondary outcomes, women in the triple-vaccinated group had higher rates of postpartum hemorrhage (9.5% vs 3.21%; P<.001) and gestational diabetes mellitus (12.2% vs 8.3%; P=.02) and were less likely to have hypertensive disorders of pregnancy (0% vs 1.4%; P=.041) than the unvaccinated group. Compared with the twice-vaccinated patients, patients with 3 doses of the vaccine were more likely to experience postpartum hemorrhage (9.5% vs 3.5%; P<.001) and were less likely to have a low umbilical artery pH (0.7% vs 6.1%; P<.001). In the sensitivity analysis comparing patients who delivered within 2 weeks of the third vaccination dose (n=53) with those who delivered at least 6 weeks after vaccination (n=96), there were no differences in the rates of small for gestational age neonates, preterm birth, postpartum hemorrhage, or cesarean delivery. !!{{ Conclusion: }} Receiving the booster dose of the SARS-CoV-2 vaccination during pregnancy was not associated with adverse obstetrical outcomes when compared with unvaccinated or twice-vaccinated women. However, higher rates of postpartum hemorrhage were observed. Further studies on a larger scale are needed to confirm these findings. | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/8988438/ | 1193 | 2589-9333 | American journal of obstetrics & gynecology MFM | [New York, NY] : Elsevier Inc. | |||
| 6458 | 114797 | COVID19(2023년) | plasma | Term | plasma | abstract | 혈장 | 36093 | https://doi.org/10.1038/s41586-022-04683-4 | Microfluidic chain reaction of structurally programmed capillary flow events | 202205 | Research | Nature | Abstract!!Chain reactions, characterized by initiation, propagation and termination, are stochastic at microscopic scales and underlie vital chemical (for example, combustion engines), nuclear and biotechnological (for example, polymerase chain reaction) applications1,2,3,4,5. At macroscopic scales, chain reactions are deterministic and limited to applications for entertainment and art such as falling dominoes and Rube Goldberg machines. On the other hand, the microfluidic lab-on-a-chip (also called a micro-total analysis system)6,7 was visualized as an integrated chip, akin to microelectronic integrated circuits, yet in practice remains dependent on cumbersome peripherals, connections and a computer for automation8,9,10,11. Capillary microfluidics integrate energy supply and flow control onto a single chip by using capillary phenomena, but programmability remains rudimentary with at most a handful (eight) operations possible12,13,14,15,16,17,18,19. Here we introduce the microfluidic chain reaction (MCR) as the conditional, structurally programmed propagation of capillary flow events. Monolithic chips integrating a MCR are three-dimensionally printed, and powered by the free energy of a paper pump, autonomously execute liquid handling algorithms step-by-step. With MCR, we automated (1) the sequential release of 300 aliquots across chained, interconnected chips, (2) a protocol for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) antibodies detection in saliva and (3) a thrombin generation assay by continuous subsampling and analysis of coagulation-activated plasma with parallel operations including timers, iterative cycles of synchronous flow and stop-flow operations. MCRs are untethered from and unencumbered by peripherals, encode programs structurally in situ and can form a frugal, versatile, bona fide lab-on-a-chip with wide-ranging applications in liquid handling and point-of-care diagnostics. | 86 | 0021-9525 | Nature | New York : Rockefeller University Press. | |||
| 6452 | 114797 | COVID19(2023년) | example | Term | example | abstract | 예 | 36093 | https://doi.org/10.1038/s41586-022-04683-4 | Microfluidic chain reaction of structurally programmed capillary flow events | 202205 | Research | Nature | Abstract!!Chain reactions, characterized by initiation, propagation and termination, are stochastic at microscopic scales and underlie vital chemical (for example, combustion engines), nuclear and biotechnological (for example, polymerase chain reaction) applications1,2,3,4,5. At macroscopic scales, chain reactions are deterministic and limited to applications for entertainment and art such as falling dominoes and Rube Goldberg machines. On the other hand, the microfluidic lab-on-a-chip (also called a micro-total analysis system)6,7 was visualized as an integrated chip, akin to microelectronic integrated circuits, yet in practice remains dependent on cumbersome peripherals, connections and a computer for automation8,9,10,11. Capillary microfluidics integrate energy supply and flow control onto a single chip by using capillary phenomena, but programmability remains rudimentary with at most a handful (eight) operations possible12,13,14,15,16,17,18,19. Here we introduce the microfluidic chain reaction (MCR) as the conditional, structurally programmed propagation of capillary flow events. Monolithic chips integrating a MCR are three-dimensionally printed, and powered by the free energy of a paper pump, autonomously execute liquid handling algorithms step-by-step. With MCR, we automated (1) the sequential release of 300 aliquots across chained, interconnected chips, (2) a protocol for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) antibodies detection in saliva and (3) a thrombin generation assay by continuous subsampling and analysis of coagulation-activated plasma with parallel operations including timers, iterative cycles of synchronous flow and stop-flow operations. MCRs are untethered from and unencumbered by peripherals, encode programs structurally in situ and can form a frugal, versatile, bona fide lab-on-a-chip with wide-ranging applications in liquid handling and point-of-care diagnostics. | 86 | 0021-9525 | Nature | New York : Rockefeller University Press. | |||
| 6456 | 114797 | COVID19(2023년) | microfluidic | Term | microfluidic | abstract | 미세 유체 | 36093 | https://doi.org/10.1038/s41586-022-04683-4 | Microfluidic chain reaction of structurally programmed capillary flow events | 202205 | Research | Nature | Abstract!!Chain reactions, characterized by initiation, propagation and termination, are stochastic at microscopic scales and underlie vital chemical (for example, combustion engines), nuclear and biotechnological (for example, polymerase chain reaction) applications1,2,3,4,5. At macroscopic scales, chain reactions are deterministic and limited to applications for entertainment and art such as falling dominoes and Rube Goldberg machines. On the other hand, the microfluidic lab-on-a-chip (also called a micro-total analysis system)6,7 was visualized as an integrated chip, akin to microelectronic integrated circuits, yet in practice remains dependent on cumbersome peripherals, connections and a computer for automation8,9,10,11. Capillary microfluidics integrate energy supply and flow control onto a single chip by using capillary phenomena, but programmability remains rudimentary with at most a handful (eight) operations possible12,13,14,15,16,17,18,19. Here we introduce the microfluidic chain reaction (MCR) as the conditional, structurally programmed propagation of capillary flow events. Monolithic chips integrating a MCR are three-dimensionally printed, and powered by the free energy of a paper pump, autonomously execute liquid handling algorithms step-by-step. With MCR, we automated (1) the sequential release of 300 aliquots across chained, interconnected chips, (2) a protocol for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) antibodies detection in saliva and (3) a thrombin generation assay by continuous subsampling and analysis of coagulation-activated plasma with parallel operations including timers, iterative cycles of synchronous flow and stop-flow operations. MCRs are untethered from and unencumbered by peripherals, encode programs structurally in situ and can form a frugal, versatile, bona fide lab-on-a-chip with wide-ranging applications in liquid handling and point-of-care diagnostics. | 86 | 0021-9525 | Nature | New York : Rockefeller University Press. | |||
| 6464 | 114797 | COVID19(2023년) | saliva | Term | saliva | abstract | 타액 | 36093 | https://doi.org/10.1038/s41586-022-04683-4 | Microfluidic chain reaction of structurally programmed capillary flow events | 202205 | Research | Nature | Abstract!!Chain reactions, characterized by initiation, propagation and termination, are stochastic at microscopic scales and underlie vital chemical (for example, combustion engines), nuclear and biotechnological (for example, polymerase chain reaction) applications1,2,3,4,5. At macroscopic scales, chain reactions are deterministic and limited to applications for entertainment and art such as falling dominoes and Rube Goldberg machines. On the other hand, the microfluidic lab-on-a-chip (also called a micro-total analysis system)6,7 was visualized as an integrated chip, akin to microelectronic integrated circuits, yet in practice remains dependent on cumbersome peripherals, connections and a computer for automation8,9,10,11. Capillary microfluidics integrate energy supply and flow control onto a single chip by using capillary phenomena, but programmability remains rudimentary with at most a handful (eight) operations possible12,13,14,15,16,17,18,19. Here we introduce the microfluidic chain reaction (MCR) as the conditional, structurally programmed propagation of capillary flow events. Monolithic chips integrating a MCR are three-dimensionally printed, and powered by the free energy of a paper pump, autonomously execute liquid handling algorithms step-by-step. With MCR, we automated (1) the sequential release of 300 aliquots across chained, interconnected chips, (2) a protocol for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) antibodies detection in saliva and (3) a thrombin generation assay by continuous subsampling and analysis of coagulation-activated plasma with parallel operations including timers, iterative cycles of synchronous flow and stop-flow operations. MCRs are untethered from and unencumbered by peripherals, encode programs structurally in situ and can form a frugal, versatile, bona fide lab-on-a-chip with wide-ranging applications in liquid handling and point-of-care diagnostics. | 86 | 0021-9525 | Nature | New York : Rockefeller University Press. | |||
| 6468 | 114797 | COVID19(2023년) | thrombin | Drug | thrombin | abstract | 트롬빈 | 36093 | https://doi.org/10.1038/s41586-022-04683-4 | Microfluidic chain reaction of structurally programmed capillary flow events | 202205 | Research | Nature | Abstract!!Chain reactions, characterized by initiation, propagation and termination, are stochastic at microscopic scales and underlie vital chemical (for example, combustion engines), nuclear and biotechnological (for example, polymerase chain reaction) applications1,2,3,4,5. At macroscopic scales, chain reactions are deterministic and limited to applications for entertainment and art such as falling dominoes and Rube Goldberg machines. On the other hand, the microfluidic lab-on-a-chip (also called a micro-total analysis system)6,7 was visualized as an integrated chip, akin to microelectronic integrated circuits, yet in practice remains dependent on cumbersome peripherals, connections and a computer for automation8,9,10,11. Capillary microfluidics integrate energy supply and flow control onto a single chip by using capillary phenomena, but programmability remains rudimentary with at most a handful (eight) operations possible12,13,14,15,16,17,18,19. Here we introduce the microfluidic chain reaction (MCR) as the conditional, structurally programmed propagation of capillary flow events. Monolithic chips integrating a MCR are three-dimensionally printed, and powered by the free energy of a paper pump, autonomously execute liquid handling algorithms step-by-step. With MCR, we automated (1) the sequential release of 300 aliquots across chained, interconnected chips, (2) a protocol for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) antibodies detection in saliva and (3) a thrombin generation assay by continuous subsampling and analysis of coagulation-activated plasma with parallel operations including timers, iterative cycles of synchronous flow and stop-flow operations. MCRs are untethered from and unencumbered by peripherals, encode programs structurally in situ and can form a frugal, versatile, bona fide lab-on-a-chip with wide-ranging applications in liquid handling and point-of-care diagnostics. | 86 | 0021-9525 | Nature | New York : Rockefeller University Press. | |||
| 6447 | 114797 | COVID19(2023년) | connection | Term | connection | abstract | 연관성 | 36093 | https://doi.org/10.1038/s41586-022-04683-4 | Microfluidic chain reaction of structurally programmed capillary flow events | 202205 | Research | Nature | Abstract!!Chain reactions, characterized by initiation, propagation and termination, are stochastic at microscopic scales and underlie vital chemical (for example, combustion engines), nuclear and biotechnological (for example, polymerase chain reaction) applications1,2,3,4,5. At macroscopic scales, chain reactions are deterministic and limited to applications for entertainment and art such as falling dominoes and Rube Goldberg machines. On the other hand, the microfluidic lab-on-a-chip (also called a micro-total analysis system)6,7 was visualized as an integrated chip, akin to microelectronic integrated circuits, yet in practice remains dependent on cumbersome peripherals, connections and a computer for automation8,9,10,11. Capillary microfluidics integrate energy supply and flow control onto a single chip by using capillary phenomena, but programmability remains rudimentary with at most a handful (eight) operations possible12,13,14,15,16,17,18,19. Here we introduce the microfluidic chain reaction (MCR) as the conditional, structurally programmed propagation of capillary flow events. Monolithic chips integrating a MCR are three-dimensionally printed, and powered by the free energy of a paper pump, autonomously execute liquid handling algorithms step-by-step. With MCR, we automated (1) the sequential release of 300 aliquots across chained, interconnected chips, (2) a protocol for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) antibodies detection in saliva and (3) a thrombin generation assay by continuous subsampling and analysis of coagulation-activated plasma with parallel operations including timers, iterative cycles of synchronous flow and stop-flow operations. MCRs are untethered from and unencumbered by peripherals, encode programs structurally in situ and can form a frugal, versatile, bona fide lab-on-a-chip with wide-ranging applications in liquid handling and point-of-care diagnostics. | 86 | 0021-9525 | Nature | New York : Rockefeller University Press. | |||
| 7517 | 114797 | COVID19(2023년) | second wave | Symptom | second wave | abstract | 두 번째 물결 | 235660 | https://doi.org/10.1007/s13760-021-01840-w | Mucormycosis in COVID-19 patients: predisposing factors, prevention and management | Pavan Kumar Rudrabhatla|||Aravind Reghukumar|||Sanjeev V Thomas | 202204 | Review | pubmed | India is considered the diabetes capital of the world and has the highest burden of mucormycosis. Bacterial, viral and fungal co-infections are increasingly being reported in severe acute respiratory syndrome virus 2 (SARSCoV-2) infected patients. India is one of the worst affected countries during the second wave of the COVID-19 pandemic. This combination of diabetes mellitus, COVID-19 and mucormycosis has led to the drastic upsurge of COVID-19-associated mucormycosis (CAM) in India. Immunosuppression, iron disequilibrium, endothelial injury, ketoacidosis and hypoxia are some of the other COVID-19-related risk factors for CAM. There has been an increase in the proportion of mucormycosis affecting paranasal sinuses and central nervous system (CNS) in CAM compared to pre-COVID-19 literature due to the SARSCoV-2-related pathophysiological mechanisms, complications and treatment strategies. CAM is a medical and surgical emergency, and it can present with non-specific symptoms and signs initially resulting in diagnostic delay. High index of suspicion and regular screening for features of CAM are of paramount importance to prevent lethal consequences. Rapid action with a tripod approach consisting of withdrawal of immunomodulators, early antifungal therapy and extensive surgical debridement is considered the best possible treatment model. We review the published data to give a detailed account of the predisposing factors and their mechanisms, diagnostic work-up, treatment modalities and prevention strategies of CAM with special emphasis on CNS mucormycosis. | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/8612391/ | 217 | 0300-9009 | Acta neurologica Belgica | Milan : Springer. | |
| 7029 | 114797 | COVID19(2023년) | Ordinal regression | Term | Ordinal regression | abstract | 232641 | https://doi.org/10.1016/j.encep.2021.03.002 | Bio-psychosocial study on the impact of the COVID-19 lockdown on depression and anxiety in a sample of 1753 French-speaking subjects | B Gouvernet|||M Bonierbale | 202204 | pubmed | The aim of this article was to study the impact of the COVID19 lockdown on anxiety and depressive symptoms on the basis of responses to an online survey from 1753 French-speaking subjects, conducted between April 27 and May 11, 2020. !!{{ Method: }} Using a biopsychosocial model, the effects of socio-demographic characteristics (age, gender at birth, socio-professional category, sexual orientation), lockdown conditions (material factors: urban density of the place of residence, surface area of the place of residence during lockdown), social characteristics: living with a partner during lockdown, presence of children during lockdown) and psychosocial history (attachment styles) on anxiety - evaluated on the GAD7 - and depression - evaluated on the MDI - were investigated. Ordinal regression analyses were conducted. !!{{ Results: }} The rates of depression observed (moderate or severe depression: 22.5%) and anxiety (moderate or severe anxiety: 18.4%) were higher than usual but lower than what has been documented in other studies on the effects of lockdown. Women appeared to be more vulnerable than men (Anxiety: AOR=1.647, CI 95%=1.647-2.530; Depression: AOR=1.622, CI 95%=1.274-2.072). Bisexual individuals had an increased likelihood of anxiety symptoms (AOR=1.962, CI 95%=1.544-2.490) and depression (AOR=1.799, CI 95%=1.394-2.317). For homosexuals, only links with depression were observed (AOR=1.757, CI 95%=1.039-2.906). People in a situation of economic vulnerability were more prone to anxiety disorders (e.g. people with no working activity: AOR=1.791, CI 95%=1.147-2.790) or depression (e.g. people with no working activity: AOR=2.581, CI 95%=1.633-4.057). Links with attachment styles were also found. Fearful subjects were particularly vulnerable (anxiety: AOR=2.514, CI 95%=1.985-3.190; depression: AOR=2.521, CI 95%=1.938-3.289), followed by subjects with an anxious attachment style (anxiety: AOR=1.949, CI 95%=1.498-2.540; depression: AOR=1.623, CI 95%=1.207-2.181). The impact of lockdown on avoidant subjects only concerned depression (AOR=1.417, CI 95%=1.034-1.937). Being with a partner during lockdown appeared to have a protective effect against depression (AOR=.693, CI 95%=.555-.866). Neither the presence of children, the surface area of the lockdown residence, nor the population density of the place of residence was associated with anxiety or depression. !!{{ Conclusion: }} The impact of lockdown on mental health depends on a range of dimensions that need to be apprehended in order to tailor post-lockdown psychological and social support. Management based on a biopsychosocial approach should be favored. | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/8015427/ | 2449 | L'Enc?phale | |||||
| 7475 | 114797 | COVID19(2023년) | antifungal therapy | Treatment | antifungal therapy | abstract | 235660 | https://doi.org/10.1007/s13760-021-01840-w | Mucormycosis in COVID-19 patients: predisposing factors, prevention and management | Pavan Kumar Rudrabhatla|||Aravind Reghukumar|||Sanjeev V Thomas | 202204 | Review | pubmed | India is considered the diabetes capital of the world and has the highest burden of mucormycosis. Bacterial, viral and fungal co-infections are increasingly being reported in severe acute respiratory syndrome virus 2 (SARSCoV-2) infected patients. India is one of the worst affected countries during the second wave of the COVID-19 pandemic. This combination of diabetes mellitus, COVID-19 and mucormycosis has led to the drastic upsurge of COVID-19-associated mucormycosis (CAM) in India. Immunosuppression, iron disequilibrium, endothelial injury, ketoacidosis and hypoxia are some of the other COVID-19-related risk factors for CAM. There has been an increase in the proportion of mucormycosis affecting paranasal sinuses and central nervous system (CNS) in CAM compared to pre-COVID-19 literature due to the SARSCoV-2-related pathophysiological mechanisms, complications and treatment strategies. CAM is a medical and surgical emergency, and it can present with non-specific symptoms and signs initially resulting in diagnostic delay. High index of suspicion and regular screening for features of CAM are of paramount importance to prevent lethal consequences. Rapid action with a tripod approach consisting of withdrawal of immunomodulators, early antifungal therapy and extensive surgical debridement is considered the best possible treatment model. We review the published data to give a detailed account of the predisposing factors and their mechanisms, diagnostic work-up, treatment modalities and prevention strategies of CAM with special emphasis on CNS mucormycosis. | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/8612391/ | 217 | 0300-9009 | Acta neurologica Belgica | Milan : Springer. | ||
| 7007 | 114797 | COVID19(2023년) | biopsychosocial | Term | biopsychosocial | abstract | 232641 | https://doi.org/10.1016/j.encep.2021.03.002 | Bio-psychosocial study on the impact of the COVID-19 lockdown on depression and anxiety in a sample of 1753 French-speaking subjects | B Gouvernet|||M Bonierbale | 202204 | pubmed | The aim of this article was to study the impact of the COVID19 lockdown on anxiety and depressive symptoms on the basis of responses to an online survey from 1753 French-speaking subjects, conducted between April 27 and May 11, 2020. !!{{ Method: }} Using a biopsychosocial model, the effects of socio-demographic characteristics (age, gender at birth, socio-professional category, sexual orientation), lockdown conditions (material factors: urban density of the place of residence, surface area of the place of residence during lockdown), social characteristics: living with a partner during lockdown, presence of children during lockdown) and psychosocial history (attachment styles) on anxiety - evaluated on the GAD7 - and depression - evaluated on the MDI - were investigated. Ordinal regression analyses were conducted. !!{{ Results: }} The rates of depression observed (moderate or severe depression: 22.5%) and anxiety (moderate or severe anxiety: 18.4%) were higher than usual but lower than what has been documented in other studies on the effects of lockdown. Women appeared to be more vulnerable than men (Anxiety: AOR=1.647, CI 95%=1.647-2.530; Depression: AOR=1.622, CI 95%=1.274-2.072). Bisexual individuals had an increased likelihood of anxiety symptoms (AOR=1.962, CI 95%=1.544-2.490) and depression (AOR=1.799, CI 95%=1.394-2.317). For homosexuals, only links with depression were observed (AOR=1.757, CI 95%=1.039-2.906). People in a situation of economic vulnerability were more prone to anxiety disorders (e.g. people with no working activity: AOR=1.791, CI 95%=1.147-2.790) or depression (e.g. people with no working activity: AOR=2.581, CI 95%=1.633-4.057). Links with attachment styles were also found. Fearful subjects were particularly vulnerable (anxiety: AOR=2.514, CI 95%=1.985-3.190; depression: AOR=2.521, CI 95%=1.938-3.289), followed by subjects with an anxious attachment style (anxiety: AOR=1.949, CI 95%=1.498-2.540; depression: AOR=1.623, CI 95%=1.207-2.181). The impact of lockdown on avoidant subjects only concerned depression (AOR=1.417, CI 95%=1.034-1.937). Being with a partner during lockdown appeared to have a protective effect against depression (AOR=.693, CI 95%=.555-.866). Neither the presence of children, the surface area of the lockdown residence, nor the population density of the place of residence was associated with anxiety or depression. !!{{ Conclusion: }} The impact of lockdown on mental health depends on a range of dimensions that need to be apprehended in order to tailor post-lockdown psychological and social support. Management based on a biopsychosocial approach should be favored. | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/8015427/ | 2449 | L'Enc?phale | |||||
| 7046 | 114797 | COVID19(2023년) | COVID-19 | Disease | COVID-19 | title | 코로나-19 | 233114 | https://doi.org/10.1080/08820538.2021.1950778 | COVID-19 Vaccine Uptake in Patients with Ocular Surface Diseases in India | Anthony Vipin Das|||Ramulu Goud|||Sayan Basu | 202202 | pubmed | None | https://pubmed.ncbi.nlm.nih.gov/34236941/ | 4615 | 0882-0538 | Seminars in ophthalmology | London : Informa Healthcare. | ||
| 7380 | 114797 | COVID19(2023년) | patients with COVID-19 | Patient | patients with COVID-19 | abstract | 235437 | https://doi.org/10.1111/jcpt.13554 | Antibiotic stewardship: Early discontinuation of antibiotics based on procalcitonin level in COVID-19 pneumonia | Archana Roy|||Harry Ross Powers|||Emily C Craver|||Mark D Nazareno|||Siva Naga S Yarrarapu|||Devang K Sanghavi | 202202 | pubmed | {{ What is known and objective: }} Procalcitonin (PCT) levels rise in systemic inflammation, especially if bacterial in origin. COVID-19, caused by the novel coronavirus SARS-CoV-2, presents with acute respiratory distress syndrome. Elevated procalcitonin in COVID-19 is considered as a marker for severity of disease. There is no study available that indicates whether elevated PCT in COVID-19 is associated with inflammation or superimposed bacterial infection. The objective of this study is to evaluate the association between PCT levels and superadded bacterial infection, and the effect of discontinuation of antibiotic in the low PCT (<0.25 ng/ml) group on patients' outcomes. !!{{ Methods: }} A retrospective chart review of patients admitted with COVID-19 pneumonia at a single tertiary care centre. We collected information on demographics, co-morbidities, PCT level, antibiotic use, culture results for bacterial infection, hospital length of stay (LOS) and mortality. !!{{ Statistical analysis: }} Continuous variables were summarized with the sample median, interquartile range, mean and range. Categorical variables were summarized with number and percentage of patients. !!{{ Results and discussion: }} We studied a total of 147 patients with COVID-19 pneumonia. 101 (69%) patients had a low PCT level (< 0.25 ng/ml). Bacterial culture results were negative for all patients, except 1 who had a markedly elevated PCT level (141.ng/ml). In patients with low PCT, 42% received no antibiotics, 59% received antibiotics initially, 32 (57%) patients antibiotic discontinued early (within 24 hours) and their culture remained negative for bacterial infections during hospitalizations. LOS was shorter (6 days in low PCT group compared to 9 days) in high PCT group. LOS was 1 day shorter (5 days vs 6 days) in no antibiotic group compared to antibiotic group. Our study examines the association between PCT level and superadded bacterial infection in COVID-19 pneumonia. Our results demonstrate that most patients admitted with COVID-19 have a low PCT (<0.25 ng/ml), which suggests no superadded bacterial infection and supports the previously published literature regarding low PCT in viral pneumonia. !!{{ What is new and conclusion: }} Procalcitonin level remains low in the absence of bacterial infection. Early de-escalation/discontinuation of antibiotics is safe without adverse outcomes in COVID-19 pneumonia. Early de-escalation/discontinuation of antibiotics is associated with lower LOS. | https://pubmed.ncbi.nlm.nih.gov/34766357/ | 404 | 0269-4727 | Journal of clinical pharmacy and therapeutics | Oxford : Wiley-Blackwell Pub. | |||
| 14629 | 114797 | COVID19(2023년) | mucormycosis | Term | mucormycosis | abstract | 털곰팡이증 | 240275 | A Novel Study of Correlation of Lipid Parameters with Clinical Profile, Staging and Onset of Rhino Orbito Cerebral Mucormycosis Covid 19 Pandemic | Vijay V|||Kavya St | 202204 | pubmed | Mucormycosis is an angioinvasive disease caused by mold fungi of the genus Rhizopus, Mucor. India has reported surge in cases of COVID 19 associated Mucormycosis over the past few months due to the increasing frequency of risk factors like corticosteroid therapy, uncontrolled diabetes, neutropenia and obesity. Studies have shown that eukaryote cell membrane contains cholesterol and fungal cell wall contains ergosterol with lanosterol being precursor for both and ergosterol is essential for mitochondrial DNA maintenance in fungi, as cholesterol is in humans. The current study is based on the hypothesis that fungi can use human cholesterol as a raw material to maintain its cell function and accentuate its own multiplication and this can indirectly be shown by the association between deranged lipid parameters in an individual with severity of Mucormycosis. Thus present study aims to estimate the lipid parameters and correlate the serum lipid parameters with clinical profile, stage of the disease and duration of onset of mucormycosis in patients with COVID associated Mucormycosis. !!{{ Material: }} This is a cross sectional study conducted on 103 patients diagnosed with COVID 19 associated mucormycosis admitted to the hospitals attached to BMCRI from July 2021 to September 2021. Serum fasting lipid profile and other biochemical parameters were determined. The correlation of lipid levels with clinical profile, onset and staging of mucormycosis patients were obtained. !!{{ Observation: }} The age distribution varied from 22yrs to 75yrs of whom majority were males (83.4%). Among patients with mucormycosis of all severity stages, nasal block (79.6%) was found to be most common symptom followed by headache(75.7%). Among patients with mucormycosis most frequent associated comorbidity was Diabetes mellitus (DM) followed by hypertension (HTN) followed by DM and HTN followed by Ischemic Heart Disease (IHD) followed by DM,HTN and IHD. The study showed statistically significant correlation such that severity of mucormycosis increased with progressive worsening lipid parameters. It also showed statistically significant correlation such that patients with increasing TC,LDL,VLDL,TG levels had shorter COVID 19 onset to mucormycosis onset duration. !!{{ Conclusion: }} The study showed a positive correlation between serum lipid profile and staging of mucormycosis and negative correlation between lipid levels with duration between onset of COVID 19 to onset of mucormycosis. Hence serum lipid profile can be used as an excellent marker to predict the severity and prognosis of COVID 19 associated mucormycosis. | https://pubmed.ncbi.nlm.nih.gov/35443508/ | 4071 | 0004-5772 | The Journal of the Association of Physicians of India | Bombay : Association of Physicians of India. | |||
| 9227 | 114797 | COVID19(2023년) | MR-PRESSO | Term | MR-PRESSO | abstract | 243067 | https://doi.org/10.1089/thy.2022.0243 | COVID-19 and Thyroid Function: A Bi-Directional Two-Sample Mendelian Randomization Study | Gloria Hoi-Yee Li|||Ching-Man Tang|||Ching-Lung Cheung | 202209 | pubmed | Background: Thyroid dysfunction has been observed among some patients with coronavirus disease (COVID-19). It is unclear whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (or its severity) leads to the development of thyroid dysfunction, or vice versa. In this study, we examined the bi-directional causal relationship between host genetic liability to three COVID-19 phenotypes (including SARS-CoV-2 infection, hospitalized and severe COVID-19) and three thyroid dysfunction traits (including hyperthyroidism, hypothyroidism, and autoimmune thyroid disease [AITD]) and three continuous traits of thyroid hormones (including thyrotropin [TSH] and free thyroxine [fT4] within reference range, and TSH in full range). Methods: Summary statistics from the largest available meta-analyses of human genome-wide association studies were retrieved for the following variables: SARS-CoV-2 infection ( n = 1,348,701), COVID-19 hospitalization ( n = 1,557,411), severe COVID-19 ( n = 1,059,456), hyperthyroidism ( n = 51,823), hypothyroidism ( n = 53,423), AITD ( n = 755,406), TSH within reference range ( n = 54,288), fT4 within reference range ( n = 49,269), and TSH in full range ( n = 119,715). Using a two-sample Mendelian randomization (MR) approach, the inverse-variance weighted (IVW) method was adopted as the main MR analysis. Weighted median, contamination mixture, MR-Egger, and MR pleiotropy residual sum and outlier (MR-PRESSO) methods were applied as sensitivity analyses. Results: Host genetic susceptibility to SARS-CoV-2 infection was causally associated with hypothyroidism in the main IVW analysis (per doubling in prevalence of SARS-CoV-2 infection, odds ratio [OR] = 1.335; 95% confidence interval [CI]: 1.167-1.526; p = 2.4 × 10^{-5}, surpassing the Bonferroni multiple-testing threshold). Similar causal estimates were observed in the sensitivity analyses (weighted median: OR = 1.296; CI: 1.066-1.575; p = 9 × 10^{-3}; contamination mixture: OR = 1.356; CI: 1.095-1.818; p = 0.013; MR-Egger: OR = 1.712; CI: 1.202-2.439; p = 2.92 × 10^{-3}, and MR-PRESSO: OR = 1.335; CI: 1.156-1.542; p = 5.73 × 10^{-4}). Host genetic liability to hospitalized or severe COVID-19 was not associated with thyroid dysfunction or thyroid hormone levels. In the reverse direction, there was no evidence to suggest that genetic predisposition to thyroid dysfunction or genetically determined thyroid hormone levels altered the risk of the COVID-19 outcomes. Conclusions: This bi-directional MR study supports that host response to SARS-CoV-2 viral infection plays a role in the causal association with increased risk of hypothyroidism. Long-term follow-up studies are needed to confirm the expected increased hypothyroidism risk. | https://pubmed.ncbi.nlm.nih.gov/35734897/ | 4630 | 1050-7256 | Thyroid : official journal of the American Thyroid Association | New York, NY : Mary Ann Liebert Publishers,. | |||
| 9235 | 114797 | COVID19(2023년) | retrieved | Action | retrieved | abstract | 243067 | https://doi.org/10.1089/thy.2022.0243 | COVID-19 and Thyroid Function: A Bi-Directional Two-Sample Mendelian Randomization Study | Gloria Hoi-Yee Li|||Ching-Man Tang|||Ching-Lung Cheung | 202209 | pubmed | Background: Thyroid dysfunction has been observed among some patients with coronavirus disease (COVID-19). It is unclear whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (or its severity) leads to the development of thyroid dysfunction, or vice versa. In this study, we examined the bi-directional causal relationship between host genetic liability to three COVID-19 phenotypes (including SARS-CoV-2 infection, hospitalized and severe COVID-19) and three thyroid dysfunction traits (including hyperthyroidism, hypothyroidism, and autoimmune thyroid disease [AITD]) and three continuous traits of thyroid hormones (including thyrotropin [TSH] and free thyroxine [fT4] within reference range, and TSH in full range). Methods: Summary statistics from the largest available meta-analyses of human genome-wide association studies were retrieved for the following variables: SARS-CoV-2 infection ( n = 1,348,701), COVID-19 hospitalization ( n = 1,557,411), severe COVID-19 ( n = 1,059,456), hyperthyroidism ( n = 51,823), hypothyroidism ( n = 53,423), AITD ( n = 755,406), TSH within reference range ( n = 54,288), fT4 within reference range ( n = 49,269), and TSH in full range ( n = 119,715). Using a two-sample Mendelian randomization (MR) approach, the inverse-variance weighted (IVW) method was adopted as the main MR analysis. Weighted median, contamination mixture, MR-Egger, and MR pleiotropy residual sum and outlier (MR-PRESSO) methods were applied as sensitivity analyses. Results: Host genetic susceptibility to SARS-CoV-2 infection was causally associated with hypothyroidism in the main IVW analysis (per doubling in prevalence of SARS-CoV-2 infection, odds ratio [OR] = 1.335; 95% confidence interval [CI]: 1.167-1.526; p = 2.4 × 10^{-5}, surpassing the Bonferroni multiple-testing threshold). Similar causal estimates were observed in the sensitivity analyses (weighted median: OR = 1.296; CI: 1.066-1.575; p = 9 × 10^{-3}; contamination mixture: OR = 1.356; CI: 1.095-1.818; p = 0.013; MR-Egger: OR = 1.712; CI: 1.202-2.439; p = 2.92 × 10^{-3}, and MR-PRESSO: OR = 1.335; CI: 1.156-1.542; p = 5.73 × 10^{-4}). Host genetic liability to hospitalized or severe COVID-19 was not associated with thyroid dysfunction or thyroid hormone levels. In the reverse direction, there was no evidence to suggest that genetic predisposition to thyroid dysfunction or genetically determined thyroid hormone levels altered the risk of the COVID-19 outcomes. Conclusions: This bi-directional MR study supports that host response to SARS-CoV-2 viral infection plays a role in the causal association with increased risk of hypothyroidism. Long-term follow-up studies are needed to confirm the expected increased hypothyroidism risk. | https://pubmed.ncbi.nlm.nih.gov/35734897/ | 4630 | 1050-7256 | Thyroid : official journal of the American Thyroid Association | New York, NY : Mary Ann Liebert Publishers,. | |||
| 9253 | 114797 | COVID19(2023년) | TSH | Molecule | TSH | abstract | 갑상선 자극 호르몬 | 243067 | https://doi.org/10.1089/thy.2022.0243 | COVID-19 and Thyroid Function: A Bi-Directional Two-Sample Mendelian Randomization Study | Gloria Hoi-Yee Li|||Ching-Man Tang|||Ching-Lung Cheung | 202209 | pubmed | Background: Thyroid dysfunction has been observed among some patients with coronavirus disease (COVID-19). It is unclear whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (or its severity) leads to the development of thyroid dysfunction, or vice versa. In this study, we examined the bi-directional causal relationship between host genetic liability to three COVID-19 phenotypes (including SARS-CoV-2 infection, hospitalized and severe COVID-19) and three thyroid dysfunction traits (including hyperthyroidism, hypothyroidism, and autoimmune thyroid disease [AITD]) and three continuous traits of thyroid hormones (including thyrotropin [TSH] and free thyroxine [fT4] within reference range, and TSH in full range). Methods: Summary statistics from the largest available meta-analyses of human genome-wide association studies were retrieved for the following variables: SARS-CoV-2 infection ( n = 1,348,701), COVID-19 hospitalization ( n = 1,557,411), severe COVID-19 ( n = 1,059,456), hyperthyroidism ( n = 51,823), hypothyroidism ( n = 53,423), AITD ( n = 755,406), TSH within reference range ( n = 54,288), fT4 within reference range ( n = 49,269), and TSH in full range ( n = 119,715). Using a two-sample Mendelian randomization (MR) approach, the inverse-variance weighted (IVW) method was adopted as the main MR analysis. Weighted median, contamination mixture, MR-Egger, and MR pleiotropy residual sum and outlier (MR-PRESSO) methods were applied as sensitivity analyses. Results: Host genetic susceptibility to SARS-CoV-2 infection was causally associated with hypothyroidism in the main IVW analysis (per doubling in prevalence of SARS-CoV-2 infection, odds ratio [OR] = 1.335; 95% confidence interval [CI]: 1.167-1.526; p = 2.4 × 10^{-5}, surpassing the Bonferroni multiple-testing threshold). Similar causal estimates were observed in the sensitivity analyses (weighted median: OR = 1.296; CI: 1.066-1.575; p = 9 × 10^{-3}; contamination mixture: OR = 1.356; CI: 1.095-1.818; p = 0.013; MR-Egger: OR = 1.712; CI: 1.202-2.439; p = 2.92 × 10^{-3}, and MR-PRESSO: OR = 1.335; CI: 1.156-1.542; p = 5.73 × 10^{-4}). Host genetic liability to hospitalized or severe COVID-19 was not associated with thyroid dysfunction or thyroid hormone levels. In the reverse direction, there was no evidence to suggest that genetic predisposition to thyroid dysfunction or genetically determined thyroid hormone levels altered the risk of the COVID-19 outcomes. Conclusions: This bi-directional MR study supports that host response to SARS-CoV-2 viral infection plays a role in the causal association with increased risk of hypothyroidism. Long-term follow-up studies are needed to confirm the expected increased hypothyroidism risk. | https://pubmed.ncbi.nlm.nih.gov/35734897/ | 4630 | 1050-7256 | Thyroid : official journal of the American Thyroid Association | New York, NY : Mary Ann Liebert Publishers,. | ||
| 9193 | 114797 | COVID19(2023년) | continuous trait | Term | continuous trait | abstract | 243067 | https://doi.org/10.1089/thy.2022.0243 | COVID-19 and Thyroid Function: A Bi-Directional Two-Sample Mendelian Randomization Study | Gloria Hoi-Yee Li|||Ching-Man Tang|||Ching-Lung Cheung | 202209 | pubmed | Background: Thyroid dysfunction has been observed among some patients with coronavirus disease (COVID-19). It is unclear whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (or its severity) leads to the development of thyroid dysfunction, or vice versa. In this study, we examined the bi-directional causal relationship between host genetic liability to three COVID-19 phenotypes (including SARS-CoV-2 infection, hospitalized and severe COVID-19) and three thyroid dysfunction traits (including hyperthyroidism, hypothyroidism, and autoimmune thyroid disease [AITD]) and three continuous traits of thyroid hormones (including thyrotropin [TSH] and free thyroxine [fT4] within reference range, and TSH in full range). Methods: Summary statistics from the largest available meta-analyses of human genome-wide association studies were retrieved for the following variables: SARS-CoV-2 infection ( n = 1,348,701), COVID-19 hospitalization ( n = 1,557,411), severe COVID-19 ( n = 1,059,456), hyperthyroidism ( n = 51,823), hypothyroidism ( n = 53,423), AITD ( n = 755,406), TSH within reference range ( n = 54,288), fT4 within reference range ( n = 49,269), and TSH in full range ( n = 119,715). Using a two-sample Mendelian randomization (MR) approach, the inverse-variance weighted (IVW) method was adopted as the main MR analysis. Weighted median, contamination mixture, MR-Egger, and MR pleiotropy residual sum and outlier (MR-PRESSO) methods were applied as sensitivity analyses. Results: Host genetic susceptibility to SARS-CoV-2 infection was causally associated with hypothyroidism in the main IVW analysis (per doubling in prevalence of SARS-CoV-2 infection, odds ratio [OR] = 1.335; 95% confidence interval [CI]: 1.167-1.526; p = 2.4 × 10^{-5}, surpassing the Bonferroni multiple-testing threshold). Similar causal estimates were observed in the sensitivity analyses (weighted median: OR = 1.296; CI: 1.066-1.575; p = 9 × 10^{-3}; contamination mixture: OR = 1.356; CI: 1.095-1.818; p = 0.013; MR-Egger: OR = 1.712; CI: 1.202-2.439; p = 2.92 × 10^{-3}, and MR-PRESSO: OR = 1.335; CI: 1.156-1.542; p = 5.73 × 10^{-4}). Host genetic liability to hospitalized or severe COVID-19 was not associated with thyroid dysfunction or thyroid hormone levels. In the reverse direction, there was no evidence to suggest that genetic predisposition to thyroid dysfunction or genetically determined thyroid hormone levels altered the risk of the COVID-19 outcomes. Conclusions: This bi-directional MR study supports that host response to SARS-CoV-2 viral infection plays a role in the causal association with increased risk of hypothyroidism. Long-term follow-up studies are needed to confirm the expected increased hypothyroidism risk. | https://pubmed.ncbi.nlm.nih.gov/35734897/ | 4630 | 1050-7256 | Thyroid : official journal of the American Thyroid Association | New York, NY : Mary Ann Liebert Publishers,. | |||
| 10005 | 114797 | COVID19(2023년) | COVID-19 | Disease | COVID-19 | title | 코로나-19 | 245179 | https://doi.org/10.1016/S1473-3099(22)00505-9 | Tackling the politicisation of COVID-19 data reporting through open access data sharing | Chad R Wells|||Alison P Galvani | 202212 | Comment | pubmed | None | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/9432865/ | 36 | 1473-3099 | The Lancet. Infectious Diseases | New York, NY : Elsevier Science ; The Lancet Pub. Group | 10.23600 |
| 10297 | 114797 | COVID19(2023년) | COVID-19 | Disease | COVID-19 | title | 코로나-19 | 245880 | https://doi.org/10.1001/jamahealthforum.2022.1980 | The Uncertain Future of Policies to Promote Access and Affordability Put in Place During the COVID-19 Pandemic | Larry Levitt | 202205 | pubmed | None | https://pubmed.ncbi.nlm.nih.gov/36219034/ | 2261 | JAMA Health Forum | ||||
| 10203 | 114797 | COVID19(2023년) | COVID-19 | Disease | COVID-19 | title | 코로나-19 | 245637 | https://doi.org/10.1001/jama.2022.13994 | Effect of Awake Prone Positioning on Patients With COVID-19 and Acute Respiratory Failure-Reply | Waleed Alhazzani|||Jason Weatherald|||Yaseen M Arabi | 202210 | Comment | pubmed | None | https://pubmed.ncbi.nlm.nih.gov/36194221/ | 1093 | 0098-7484 | JAMA | Chicago : American Medical Association | |
| 11745 | 114797 | COVID19(2023년) | membrane protein | Protein | membrane protein | abstract | 막 단백질 | 15005 | https://doi.org/10.1016/j.compbiolchem.2022.107687 | Computational study and design of effective siRNAs to silence structural proteins associated genes of Indian SARS-CoV-2 strains | Premnath Madanagopal|||Harshini Muthukumar|||Kothai Thiruvengadam | 202206 | Article | PMC | {{{ Abstract }}} !! SARS-CoV-2 is a highly transmissible and pathogenic coronavirus that first emerged in late 2019 and has since triggered a pandemic of acute respiratory disease named COVID-19 which poses a significant threat to all public health institutions in the absence of specific antiviral treatment. Since the outbreak began in March 2020, India has reported 4.77 lakh Coronavirus deaths, according to the World Health Organization (WHO). The innate RNA interference (RNAi) pathway, on the other hand, allows for the development of nucleic acid-based antiviral drugs in which complementary small interfering RNAs (siRNAs) mediate the post-transcriptional gene silencing (PTGS) of target mRNA. Therefore, in this current study, the potential of RNAi was harnessed to construct siRNA molecules that target the consensus regions of specific structural proteins associated genes of SARS-CoV-2, such as the envelope protein gene (E), membrane protein gene (M), nucleocapsid phosphoprotein gene (N), and surface glycoprotein gene (S) which are important for the viral pathogenesis. Conserved sequences of 811 SARS-CoV-2 strains from around India were collected to design 21 nucleotides long siRNA duplex based on various computational algorithms and parameters targeting E, M, N and S genes. The proposed siRNA molecules possessed sufficient nucleotide-based and other features for effective gene silencing and BLAST results revealed that siRNAs' targets have no significant matches across the whole human genome. Hence, siRNAs were found to have no off-target effects on the genome, ruling out the possibility of off-target silencing. Finally, out of 157 computationally identified siRNAs, only 4 effective siRNA molecules were selected for each target gene which is proposed to exert the best action based on GC content, free energy of folding, free energy of binding, melting temperature, heat capacity and molecular docking analysis with Human AGO2 protein. Our engineered siRNA candidates could be used as a genome-level therapeutic treatment against various sequenced SARS-CoV-2 strains in India. However, future applications will necessitate additional validations in vitro and in vivo animal models. !!{{ Keywords: }} COVID-19; Docking; Gene silencing; RNA interference; SiRNA. | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/9052778/ | 402 | 1476-9271 | Computational biology and chemistry | Oxford : Elsevier. | |
| 11917 | 114797 | COVID19(2023년) | circulating | Action | circulating | abstract | 순환 | 16933 | https://doi.org/10.1210/endrev/bnab035 | The Multifaceted Biology of PCSK9 | Nabil G Seidah|||Annik Prat | 202205 | Review | PMC | {{{ Abstract }}} !! This article reviews the discovery of PCSK9, its structure-function characteristics, and its presently known and proposed novel biological functions. The major critical function of PCSK9 deduced from human and mouse studies, as well as cellular and structural analyses, is its role in increasing the levels of circulating low-density lipoprotein (LDL)-cholesterol (LDLc), via its ability to enhance the sorting and escort of the cell surface LDL receptor (LDLR) to lysosomes. This implicates the binding of the catalytic domain of PCSK9 to the EGF-A domain of the LDLR. This also requires the presence of the C-terminal Cys/His-rich domain, its binding to the secreted cytosolic cyclase associated protein 1, and possibly another membrane-bound protein X. Curiously, in PCSK9-deficient mice, an alternative to the downregulation of the surface levels of the LDLR by PCSK9 is taking place in the liver of female mice in a 17β-estradiol-dependent manner by still an unknown mechanism. Recent studies have extended our understanding of the biological functions of PCSK9, namely its implication in septic shock, vascular inflammation, viral infections (Dengue; SARS-CoV-2) or immune checkpoint modulation in cancer via the regulation of the cell surface levels of the T-cell receptor and MHC-I, which govern the antitumoral activity of CD8+ T cells. Because PCSK9 inhibition may be advantageous in these processes, the availability of injectable safe PCSK9 inhibitors that reduces by 50% to 60% LDLc above the effect of statins is highly valuable. Indeed, injectable PCSK9 monoclonal antibody or small interfering RNA could be added to current immunotherapies in cancer/metastasis. !!{{ Keywords: }} cancer/metastases; hypercholesterolemia; major histocompatibility complex I; sepsis; β-cells. | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/9113161/ | 1700 | 0163-769X | Endocrine reviews | New York : Oxford University Press. | |
| 12525 | 114797 | COVID19(2023년) | Recurrent | Term | Recurrent | title | 재발 | 21809 | https://doi.org/10.3389/fimmu.2022.825075 | Chronic Inflammatory Placental Disorders Associated With Recurrent Adverse Pregnancy Outcome | Emily F Cornish|||Thomas McDonnell|||David J Williams | 202204 | Review | PMC | {{{ Abstract }}} !! Chronic inflammatory placental disorders are a group of rare but devastating gestational syndromes associated with adverse pregnancy outcome. This review focuses on three related conditions: villitis of unknown etiology (VUE), chronic histiocytic intervillositis (CHI) and massive perivillous fibrin deposition (MPFD). The hallmark of these disorders is infiltration of the placental architecture by maternal immune cells and disruption of the intervillous space, where gas exchange between the mother and fetus occurs. Currently, they can only be detected through histopathological examination of the placenta after a pregnancy has ended. All three are associated with a significant risk of recurrence in subsequent pregnancies. Villitis of unknown etiology is characterised by a destructive infiltrate of maternal CD8+ T lymphocytes invading into the chorionic villi, combined with activation of fetal villous macrophages. The diagnosis can only be made when an infectious aetiology has been excluded. VUE becomes more common as pregnancy progresses and is frequently seen with normal pregnancy outcome. However, severe early-onset villitis is usually associated with fetal growth restriction and recurrent pregnancy loss. Chronic histiocytic intervillositis is characterised by excessive accumulation of maternal CD68+ histiocytes in the intervillous space. It is associated with a wide spectrum of adverse pregnancy outcomes including high rates of first-trimester miscarriage, severe fetal growth restriction and late intrauterine fetal death. Intervillous histiocytes can also accumulate due to infection, including SARS-CoV-2, although this infection-induced intervillositis does not appear to recur. As with VUE, the diagnosis of CHI requires exclusion of an infectious cause. Women with recurrent CHI and their families are predisposed to autoimmune diseases, suggesting CHI may have an alloimmune pathology. This observation has driven attempts to prevent CHI with a wide range of maternal immunosuppression. Massive perivillous fibrin deposition is diagnosed when >25% of the intervillous space is occupied by fibrin, and is associated with fetal growth restriction and late intrauterine fetal death. Although not an inflammatory disorder per se, MPFD is frequently seen in association with both VUE and CHI. This review summarises current understanding of the prevalence, diagnostic features, clinical consequences, immune pathology and potential prophylaxis against recurrence in these three chronic inflammatory placental syndromes. !!{{ Keywords: }} CD8+ T lymphocytes; allograft rejection; chronic histiocytic intervillositis; chronic placental inflammation; fetal growth restriction; massive perivillous fibrin deposition; stillbirth; villitis of unknown etiology. | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/9072631/ | 109 | 1664-3224 | Frontiers in Immunology | [Lausanne : Frontiers Research Foundation]. | |
| 12905 | 114797 | COVID19(2023년) | animal model | Term | animal model | title | 동물모델 | 207404 | https://doi.org/10.1177/03009858221096502 | Special focus on SARS-CoV-2 and other zoonotic respiratory coronaviruses in animal models | Hibret A Adissu|||David K Meyerholz|||Amanda J Martinot|||Jerrold M Ward | 202207 | Editorial | pubmed | None | https://pubmed.ncbi.nlm.nih.gov/35713355/ | 1191 | 0300-9858 | Veterinary pathology | Thousand Oaks, CA : Sage. | |
| 14600 | 114797 | COVID19(2023년) | corticosteroid therapy | Treatment | corticosteroid therapy | abstract | 240275 | A Novel Study of Correlation of Lipid Parameters with Clinical Profile, Staging and Onset of Rhino Orbito Cerebral Mucormycosis Covid 19 Pandemic | Vijay V|||Kavya St | 202204 | pubmed | Mucormycosis is an angioinvasive disease caused by mold fungi of the genus Rhizopus, Mucor. India has reported surge in cases of COVID 19 associated Mucormycosis over the past few months due to the increasing frequency of risk factors like corticosteroid therapy, uncontrolled diabetes, neutropenia and obesity. Studies have shown that eukaryote cell membrane contains cholesterol and fungal cell wall contains ergosterol with lanosterol being precursor for both and ergosterol is essential for mitochondrial DNA maintenance in fungi, as cholesterol is in humans. The current study is based on the hypothesis that fungi can use human cholesterol as a raw material to maintain its cell function and accentuate its own multiplication and this can indirectly be shown by the association between deranged lipid parameters in an individual with severity of Mucormycosis. Thus present study aims to estimate the lipid parameters and correlate the serum lipid parameters with clinical profile, stage of the disease and duration of onset of mucormycosis in patients with COVID associated Mucormycosis. !!{{ Material: }} This is a cross sectional study conducted on 103 patients diagnosed with COVID 19 associated mucormycosis admitted to the hospitals attached to BMCRI from July 2021 to September 2021. Serum fasting lipid profile and other biochemical parameters were determined. The correlation of lipid levels with clinical profile, onset and staging of mucormycosis patients were obtained. !!{{ Observation: }} The age distribution varied from 22yrs to 75yrs of whom majority were males (83.4%). Among patients with mucormycosis of all severity stages, nasal block (79.6%) was found to be most common symptom followed by headache(75.7%). Among patients with mucormycosis most frequent associated comorbidity was Diabetes mellitus (DM) followed by hypertension (HTN) followed by DM and HTN followed by Ischemic Heart Disease (IHD) followed by DM,HTN and IHD. The study showed statistically significant correlation such that severity of mucormycosis increased with progressive worsening lipid parameters. It also showed statistically significant correlation such that patients with increasing TC,LDL,VLDL,TG levels had shorter COVID 19 onset to mucormycosis onset duration. !!{{ Conclusion: }} The study showed a positive correlation between serum lipid profile and staging of mucormycosis and negative correlation between lipid levels with duration between onset of COVID 19 to onset of mucormycosis. Hence serum lipid profile can be used as an excellent marker to predict the severity and prognosis of COVID 19 associated mucormycosis. | https://pubmed.ncbi.nlm.nih.gov/35443508/ | 4071 | 0004-5772 | The Journal of the Association of Physicians of India | Bombay : Association of Physicians of India. | ||||
| 14602 | 114797 | COVID19(2023년) | COVID 19 | Disease | COVID 19 | abstract | 코로나 19 | 240275 | A Novel Study of Correlation of Lipid Parameters with Clinical Profile, Staging and Onset of Rhino Orbito Cerebral Mucormycosis Covid 19 Pandemic | Vijay V|||Kavya St | 202204 | pubmed | Mucormycosis is an angioinvasive disease caused by mold fungi of the genus Rhizopus, Mucor. India has reported surge in cases of COVID 19 associated Mucormycosis over the past few months due to the increasing frequency of risk factors like corticosteroid therapy, uncontrolled diabetes, neutropenia and obesity. Studies have shown that eukaryote cell membrane contains cholesterol and fungal cell wall contains ergosterol with lanosterol being precursor for both and ergosterol is essential for mitochondrial DNA maintenance in fungi, as cholesterol is in humans. The current study is based on the hypothesis that fungi can use human cholesterol as a raw material to maintain its cell function and accentuate its own multiplication and this can indirectly be shown by the association between deranged lipid parameters in an individual with severity of Mucormycosis. Thus present study aims to estimate the lipid parameters and correlate the serum lipid parameters with clinical profile, stage of the disease and duration of onset of mucormycosis in patients with COVID associated Mucormycosis. !!{{ Material: }} This is a cross sectional study conducted on 103 patients diagnosed with COVID 19 associated mucormycosis admitted to the hospitals attached to BMCRI from July 2021 to September 2021. Serum fasting lipid profile and other biochemical parameters were determined. The correlation of lipid levels with clinical profile, onset and staging of mucormycosis patients were obtained. !!{{ Observation: }} The age distribution varied from 22yrs to 75yrs of whom majority were males (83.4%). Among patients with mucormycosis of all severity stages, nasal block (79.6%) was found to be most common symptom followed by headache(75.7%). Among patients with mucormycosis most frequent associated comorbidity was Diabetes mellitus (DM) followed by hypertension (HTN) followed by DM and HTN followed by Ischemic Heart Disease (IHD) followed by DM,HTN and IHD. The study showed statistically significant correlation such that severity of mucormycosis increased with progressive worsening lipid parameters. It also showed statistically significant correlation such that patients with increasing TC,LDL,VLDL,TG levels had shorter COVID 19 onset to mucormycosis onset duration. !!{{ Conclusion: }} The study showed a positive correlation between serum lipid profile and staging of mucormycosis and negative correlation between lipid levels with duration between onset of COVID 19 to onset of mucormycosis. Hence serum lipid profile can be used as an excellent marker to predict the severity and prognosis of COVID 19 associated mucormycosis. | https://pubmed.ncbi.nlm.nih.gov/35443508/ | 4071 | 0004-5772 | The Journal of the Association of Physicians of India | Bombay : Association of Physicians of India. | |||
| 14687 | 114797 | COVID19(2023년) | Nonlinear systems | Term | Nonlinear system | author | 넌리니어 | 240290 | https://doi.org/10.1186/s12874-022-01579-9 | Data-driven prediction of COVID-19 cases in Germany for decision making | Lukas Refisch|||Fabian Lorenz|||Torsten Riedlinger|||Hannes Taubenb?ck|||Martina Fischer|||Linus Grabenhenrich|||Martin Wolkewitz|||Harald Binder|||Clemens Kreutz | 202204 | pubmed | {{ Background: }} The COVID-19 pandemic has led to a high interest in mathematical models describing and predicting the diverse aspects and implications of the virus outbreak. Model results represent an important part of the information base for the decision process on different administrative levels. The Robert-Koch-Institute (RKI) initiated a project whose main goal is to predict COVID-19-specific occupation of beds in intensive care units: Steuerungs-Prognose von Intensivmedizinischen COVID-19 Kapazit?ten (SPoCK). The incidence of COVID-19 cases is a crucial predictor for this occupation. !!{{ Methods: }} We developed a model based on ordinary differential equations for the COVID-19 spread with a time-dependent infection rate described by a spline. Furthermore, the model explicitly accounts for weekday-specific reporting and adjusts for reporting delay. The model is calibrated in a purely data-driven manner by a maximum likelihood approach. Uncertainties are evaluated using the profile likelihood method. The uncertainty about the appropriate modeling assumptions can be accounted for by including and merging results of different modelling approaches. The analysis uses data from Germany describing the COVID-19 spread from early 2020 until March 31st, 2021. !!{{ Results: }} The model is calibrated based on incident cases on a daily basis and provides daily predictions of incident COVID-19 cases for the upcoming three weeks including uncertainty estimates for Germany and its subregions. Derived quantities such as cumulative counts and 7-day incidences with corresponding uncertainties can be computed. The estimation of the time-dependent infection rate leads to an estimated reproduction factor that is oscillating around one. Data-driven estimation of the dark figure purely from incident cases is not feasible. !!{{ Conclusions: }} We successfully implemented a procedure to forecast near future COVID-19 incidences for diverse subregions in Germany which are made available to various decision makers via an interactive web application. Results of the incidence modeling are also used as a predictor for forecasting the need of intensive care units. | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/9019290/ | 119 | 1471-2288 | BMC Medical Research Methodology | London : BioMed Central | ||
| 14615 | 114797 | COVID19(2023년) | hypertension | Disease | hypertension | abstract | 고혈압 | 240275 | A Novel Study of Correlation of Lipid Parameters with Clinical Profile, Staging and Onset of Rhino Orbito Cerebral Mucormycosis Covid 19 Pandemic | Vijay V|||Kavya St | 202204 | pubmed | Mucormycosis is an angioinvasive disease caused by mold fungi of the genus Rhizopus, Mucor. India has reported surge in cases of COVID 19 associated Mucormycosis over the past few months due to the increasing frequency of risk factors like corticosteroid therapy, uncontrolled diabetes, neutropenia and obesity. Studies have shown that eukaryote cell membrane contains cholesterol and fungal cell wall contains ergosterol with lanosterol being precursor for both and ergosterol is essential for mitochondrial DNA maintenance in fungi, as cholesterol is in humans. The current study is based on the hypothesis that fungi can use human cholesterol as a raw material to maintain its cell function and accentuate its own multiplication and this can indirectly be shown by the association between deranged lipid parameters in an individual with severity of Mucormycosis. Thus present study aims to estimate the lipid parameters and correlate the serum lipid parameters with clinical profile, stage of the disease and duration of onset of mucormycosis in patients with COVID associated Mucormycosis. !!{{ Material: }} This is a cross sectional study conducted on 103 patients diagnosed with COVID 19 associated mucormycosis admitted to the hospitals attached to BMCRI from July 2021 to September 2021. Serum fasting lipid profile and other biochemical parameters were determined. The correlation of lipid levels with clinical profile, onset and staging of mucormycosis patients were obtained. !!{{ Observation: }} The age distribution varied from 22yrs to 75yrs of whom majority were males (83.4%). Among patients with mucormycosis of all severity stages, nasal block (79.6%) was found to be most common symptom followed by headache(75.7%). Among patients with mucormycosis most frequent associated comorbidity was Diabetes mellitus (DM) followed by hypertension (HTN) followed by DM and HTN followed by Ischemic Heart Disease (IHD) followed by DM,HTN and IHD. The study showed statistically significant correlation such that severity of mucormycosis increased with progressive worsening lipid parameters. It also showed statistically significant correlation such that patients with increasing TC,LDL,VLDL,TG levels had shorter COVID 19 onset to mucormycosis onset duration. !!{{ Conclusion: }} The study showed a positive correlation between serum lipid profile and staging of mucormycosis and negative correlation between lipid levels with duration between onset of COVID 19 to onset of mucormycosis. Hence serum lipid profile can be used as an excellent marker to predict the severity and prognosis of COVID 19 associated mucormycosis. | https://pubmed.ncbi.nlm.nih.gov/35443508/ | 4071 | 0004-5772 | The Journal of the Association of Physicians of India | Bombay : Association of Physicians of India. | |||
| 14587 | 114797 | COVID19(2023년) | association | Term | association | abstract | 연관성 | 240275 | A Novel Study of Correlation of Lipid Parameters with Clinical Profile, Staging and Onset of Rhino Orbito Cerebral Mucormycosis Covid 19 Pandemic | Vijay V|||Kavya St | 202204 | pubmed | Mucormycosis is an angioinvasive disease caused by mold fungi of the genus Rhizopus, Mucor. India has reported surge in cases of COVID 19 associated Mucormycosis over the past few months due to the increasing frequency of risk factors like corticosteroid therapy, uncontrolled diabetes, neutropenia and obesity. Studies have shown that eukaryote cell membrane contains cholesterol and fungal cell wall contains ergosterol with lanosterol being precursor for both and ergosterol is essential for mitochondrial DNA maintenance in fungi, as cholesterol is in humans. The current study is based on the hypothesis that fungi can use human cholesterol as a raw material to maintain its cell function and accentuate its own multiplication and this can indirectly be shown by the association between deranged lipid parameters in an individual with severity of Mucormycosis. Thus present study aims to estimate the lipid parameters and correlate the serum lipid parameters with clinical profile, stage of the disease and duration of onset of mucormycosis in patients with COVID associated Mucormycosis. !!{{ Material: }} This is a cross sectional study conducted on 103 patients diagnosed with COVID 19 associated mucormycosis admitted to the hospitals attached to BMCRI from July 2021 to September 2021. Serum fasting lipid profile and other biochemical parameters were determined. The correlation of lipid levels with clinical profile, onset and staging of mucormycosis patients were obtained. !!{{ Observation: }} The age distribution varied from 22yrs to 75yrs of whom majority were males (83.4%). Among patients with mucormycosis of all severity stages, nasal block (79.6%) was found to be most common symptom followed by headache(75.7%). Among patients with mucormycosis most frequent associated comorbidity was Diabetes mellitus (DM) followed by hypertension (HTN) followed by DM and HTN followed by Ischemic Heart Disease (IHD) followed by DM,HTN and IHD. The study showed statistically significant correlation such that severity of mucormycosis increased with progressive worsening lipid parameters. It also showed statistically significant correlation such that patients with increasing TC,LDL,VLDL,TG levels had shorter COVID 19 onset to mucormycosis onset duration. !!{{ Conclusion: }} The study showed a positive correlation between serum lipid profile and staging of mucormycosis and negative correlation between lipid levels with duration between onset of COVID 19 to onset of mucormycosis. Hence serum lipid profile can be used as an excellent marker to predict the severity and prognosis of COVID 19 associated mucormycosis. | https://pubmed.ncbi.nlm.nih.gov/35443508/ | 4071 | 0004-5772 | The Journal of the Association of Physicians of India | Bombay : Association of Physicians of India. | |||
| 18674 | 114797 | COVID19(2023년) | Union | Term | Union | abstract | 234718 | https://doi.org/10.1080/14767058.2021.1986482 | Breastfeeding supportive practices in European hospitals during the COVID-19 pandemic | Anne Merewood|||Riccardo Davanzo|||Maetal Haas-Kogan|||Giulia Vertecchi|||Camilla Gizzi|||Fabio Mosca|||Laura Burnham|||Corrado Moretti | 202212 | pubmed | {{ Introduction: }} During the first year of the COVID-19 pandemic, international recommendations and guidelines regarding breastfeeding-supportive hospital practices changed frequently. For example, some recommended separation of mothers and infants; others, feeding pumped milk instead of milk fed directly from the breast. Many recommendations were inconsistent or in direct conflict with each other. Guidance from UENPS (the Union of European Neonatal and Perinatal Societies) published in April 2020 recommended rooming in and direct breastfeeding where feasible, under strict measures of infection control, for women who were COVID-19 positive or under investigation for COVID-19. !!{{ Key findings: }} Our study assessed data from respondents from 124 hospitals in 22 nations, with over 1000 births per year, who completed a survey on practices during the COVID-19 epidemic, as they related to the World Health Organization (WHO) Ten Steps to Successful Breastfeeding, considered to be the gold standard for breastfeeding support. The survey was conducted in the fall of 2020/winter of 2021. Overall 88% of responding hospitals had managed COVID positive mothers, and 7% had treated over 50 birthing women with confirmed COVID-19. The biggest change to hospital policy related to visitation policies, with 38% of hospitals disallowing all visitors for birthing women, and 19% shortening the postpartum stay. Eight hospitals (6%) recommended formula feeding instead of breastfeeding for women who tested positive for COVID-19 or were under investigation, whereas 73% continued to recommend direct, exclusive breastfeeding, but with some form of protection such as a mask or hand sanitizer for the mother or cleaning the breast before the feed. While 6% of hospitals discontinued rooming in, 31% strengthened their rooming in policy (keeping mothers and their babies together in the same room) to protect infants against possible exposure to the virus elsewhere in the hospital . Overall, 72% of hospitals used their country's national guidelines when making policy, 31% used WHO guidelines and 22% UENPS/SIN guidelines. Many European hospitals relied on more than one accredited source. !!{{ Discussion: }} Our most concerning finding was that 6% of hospitals recommended formula feeding for COVID positive mothers, a measure that was later shown to be potentially harmful, as protection against the virus is transmitted through human milk. It is encouraging to note that a third of hospitals strengthened rooming in measures. Especially given the emergence of the highly transmissible Delta variant, the situation around postnatal care in maternity hospitals requires ongoing monitoring and may require proactive investment to regain pre-COVID era practices. | https://pubmed.ncbi.nlm.nih.gov/34645354/ | 2363 | The journal of maternal-fetal & neonatal medicine | |||||
| 18675 | 114797 | COVID19(2023년) | virus | Virus | virus | abstract | 바이러스 | 234718 | https://doi.org/10.1080/14767058.2021.1986482 | Breastfeeding supportive practices in European hospitals during the COVID-19 pandemic | Anne Merewood|||Riccardo Davanzo|||Maetal Haas-Kogan|||Giulia Vertecchi|||Camilla Gizzi|||Fabio Mosca|||Laura Burnham|||Corrado Moretti | 202212 | pubmed | {{ Introduction: }} During the first year of the COVID-19 pandemic, international recommendations and guidelines regarding breastfeeding-supportive hospital practices changed frequently. For example, some recommended separation of mothers and infants; others, feeding pumped milk instead of milk fed directly from the breast. Many recommendations were inconsistent or in direct conflict with each other. Guidance from UENPS (the Union of European Neonatal and Perinatal Societies) published in April 2020 recommended rooming in and direct breastfeeding where feasible, under strict measures of infection control, for women who were COVID-19 positive or under investigation for COVID-19. !!{{ Key findings: }} Our study assessed data from respondents from 124 hospitals in 22 nations, with over 1000 births per year, who completed a survey on practices during the COVID-19 epidemic, as they related to the World Health Organization (WHO) Ten Steps to Successful Breastfeeding, considered to be the gold standard for breastfeeding support. The survey was conducted in the fall of 2020/winter of 2021. Overall 88% of responding hospitals had managed COVID positive mothers, and 7% had treated over 50 birthing women with confirmed COVID-19. The biggest change to hospital policy related to visitation policies, with 38% of hospitals disallowing all visitors for birthing women, and 19% shortening the postpartum stay. Eight hospitals (6%) recommended formula feeding instead of breastfeeding for women who tested positive for COVID-19 or were under investigation, whereas 73% continued to recommend direct, exclusive breastfeeding, but with some form of protection such as a mask or hand sanitizer for the mother or cleaning the breast before the feed. While 6% of hospitals discontinued rooming in, 31% strengthened their rooming in policy (keeping mothers and their babies together in the same room) to protect infants against possible exposure to the virus elsewhere in the hospital . Overall, 72% of hospitals used their country's national guidelines when making policy, 31% used WHO guidelines and 22% UENPS/SIN guidelines. Many European hospitals relied on more than one accredited source. !!{{ Discussion: }} Our most concerning finding was that 6% of hospitals recommended formula feeding for COVID positive mothers, a measure that was later shown to be potentially harmful, as protection against the virus is transmitted through human milk. It is encouraging to note that a third of hospitals strengthened rooming in measures. Especially given the emergence of the highly transmissible Delta variant, the situation around postnatal care in maternity hospitals requires ongoing monitoring and may require proactive investment to regain pre-COVID era practices. | https://pubmed.ncbi.nlm.nih.gov/34645354/ | 2363 | The journal of maternal-fetal & neonatal medicine | ||||
| 15028 | 114797 | COVID19(2023년) | Better | Term | Better | title | 241849 | https://doi.org/10.1513/AnnalsATS.202204-306VP | Procedure Codes for Intubated Prone Positioning: A Turn for the Better | Anica C Law|||Nicholas A Bosch|||Allan J Walkey | 202210 | pubmed | None | https://pubmed.ncbi.nlm.nih.gov/35608404/ | 1165 | 2329-6933 | Annals of the American Thoracic Society | New York, NY : American Thoracic Society | 1.77000 | ||
| 18677 | 114797 | COVID19(2023년) | WHO | Institution | WHO | abstract | 234718 | https://doi.org/10.1080/14767058.2021.1986482 | Breastfeeding supportive practices in European hospitals during the COVID-19 pandemic | Anne Merewood|||Riccardo Davanzo|||Maetal Haas-Kogan|||Giulia Vertecchi|||Camilla Gizzi|||Fabio Mosca|||Laura Burnham|||Corrado Moretti | 202212 | pubmed | {{ Introduction: }} During the first year of the COVID-19 pandemic, international recommendations and guidelines regarding breastfeeding-supportive hospital practices changed frequently. For example, some recommended separation of mothers and infants; others, feeding pumped milk instead of milk fed directly from the breast. Many recommendations were inconsistent or in direct conflict with each other. Guidance from UENPS (the Union of European Neonatal and Perinatal Societies) published in April 2020 recommended rooming in and direct breastfeeding where feasible, under strict measures of infection control, for women who were COVID-19 positive or under investigation for COVID-19. !!{{ Key findings: }} Our study assessed data from respondents from 124 hospitals in 22 nations, with over 1000 births per year, who completed a survey on practices during the COVID-19 epidemic, as they related to the World Health Organization (WHO) Ten Steps to Successful Breastfeeding, considered to be the gold standard for breastfeeding support. The survey was conducted in the fall of 2020/winter of 2021. Overall 88% of responding hospitals had managed COVID positive mothers, and 7% had treated over 50 birthing women with confirmed COVID-19. The biggest change to hospital policy related to visitation policies, with 38% of hospitals disallowing all visitors for birthing women, and 19% shortening the postpartum stay. Eight hospitals (6%) recommended formula feeding instead of breastfeeding for women who tested positive for COVID-19 or were under investigation, whereas 73% continued to recommend direct, exclusive breastfeeding, but with some form of protection such as a mask or hand sanitizer for the mother or cleaning the breast before the feed. While 6% of hospitals discontinued rooming in, 31% strengthened their rooming in policy (keeping mothers and their babies together in the same room) to protect infants against possible exposure to the virus elsewhere in the hospital . Overall, 72% of hospitals used their country's national guidelines when making policy, 31% used WHO guidelines and 22% UENPS/SIN guidelines. Many European hospitals relied on more than one accredited source. !!{{ Discussion: }} Our most concerning finding was that 6% of hospitals recommended formula feeding for COVID positive mothers, a measure that was later shown to be potentially harmful, as protection against the virus is transmitted through human milk. It is encouraging to note that a third of hospitals strengthened rooming in measures. Especially given the emergence of the highly transmissible Delta variant, the situation around postnatal care in maternity hospitals requires ongoing monitoring and may require proactive investment to regain pre-COVID era practices. | https://pubmed.ncbi.nlm.nih.gov/34645354/ | 2363 | The journal of maternal-fetal & neonatal medicine | |||||
| 17733 | 114797 | COVID19(2023년) | returned | Action | returned | abstract | 30945 | https://doi.org/10.1016/j.ajem.2022.04.052 | Safety and practicality of high dose inhaled nitric oxide in emergency department COVID-19 patients | Brian Strickland|||Lorenzo Albala|||El Centro Coffey|||Ryan W Carroll|||Warren M Zapol|||Fumito Ichinose|||Lorenzo Berra|||N Stuart Harris | 202208 | Trial | PMC | {{{ Abstract }}} !!{{ Background: }} Inhaled nitric oxide (iNO) is a selective pulmonary vasodilator and mild bronchodilator that has been shown to improve systemic oxygenation, but has rarely been administered in the Emergency Department (ED). In addition to its favorable pulmonary vascular effects, in-vitro studies report that NO donors can inhibit replication of viruses, including SARS Coronavirus 2 (SARS-CoV-2). This study evaluated the administration of high-dose iNO by mask in spontaneously breathing emergency department (ED) patients with respiratory symptoms attributed to Coronavirus disease 2019 (COVID-19). !!{{ Methods: }} We designed a randomized clinical trial to determine whether 30 min of high dose iNO (250 ppm) could be safely and practically administered by emergency physicians in the ED to spontaneously-breathing patients with respiratory symptoms attributed to COVID-19. Our secondary goal was to learn if iNO could prevent the progression of mild COVID-19 to a more severe state. !!{{ Findings: }} We enrolled 47 ED patients with acute respiratory symptoms most likely due to COVID-19: 25 of 47 (53%) were randomized to the iNO treatment group; 22 of 47 (46%) to the control group (supportive care only). All patients tolerated the administration of high-dose iNO in the ED without significant complications or symptoms. Five patients receiving iNO (16%) experienced asymptomatic methemoglobinemia (MetHb) > 5%. Thirty-four of 47 (72%) subjects tested positive for SARS-CoV-2: 19 of 34 were randomized to the iNO treatment group and 15 of 34 subjects to the control group. Seven of 19 (38%) iNO patients returned to the ED, while 4 of 15 (27%) control patients did. One patient in each study arm was hospitalized: 5% in iNO treatment and 7% in controls. One patient was intubated in the iNO group. No patients in either group died. The differences between these groups were not significant. !!{{ Conclusion: }} A single dose of iNO at 250 ppm was practical and not associated with any significant adverse effects when administered in the ED by emergency physicians. Local disease control led to early study closure and prevented complete testing of COVID-19 safety and treatment outcomes measures. !!{{ Keywords: }} COVID-19; Emergency department; Nitric oxide. | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/9066706/ | 231 | 0735-6757 | The American journal of emergency medicine | Philadelphia, PA : W B Saunders. | ||
| 16061 | 114797 | COVID19(2023년) | biomarker | Term | biomarker | title | 바이오마커 | 245953 | https://doi.org/10.1002/jmv.28213 | In response to: Disease severity and efficacy of homologous vaccination among patients infected with SARS-CoV-2 Delta or Omicron VOCs, compared to unvaccinated using main biomarkers | Sherko S Niranji|||Sirwan M Amin Al-Jaf | 202301 | Comment | pubmed | None | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/9874565/ | 274 | 0146-6615 | Journal of medical virology | New York Ny : Wiley-Liss. | 2.65600 |
| 16062 | 114797 | COVID19(2023년) | Delta | Term | Delta | title | 델타 | 245953 | https://doi.org/10.1002/jmv.28213 | In response to: Disease severity and efficacy of homologous vaccination among patients infected with SARS-CoV-2 Delta or Omicron VOCs, compared to unvaccinated using main biomarkers | Sherko S Niranji|||Sirwan M Amin Al-Jaf | 202301 | Comment | pubmed | None | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/9874565/ | 274 | 0146-6615 | Journal of medical virology | New York Ny : Wiley-Liss. | 2.65600 |
| 16069 | 114797 | COVID19(2023년) | vaccination | Treatment | vaccination | title | 백신 접종 | 245953 | https://doi.org/10.1002/jmv.28213 | In response to: Disease severity and efficacy of homologous vaccination among patients infected with SARS-CoV-2 Delta or Omicron VOCs, compared to unvaccinated using main biomarkers | Sherko S Niranji|||Sirwan M Amin Al-Jaf | 202301 | Comment | pubmed | None | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/9874565/ | 274 | 0146-6615 | Journal of medical virology | New York Ny : Wiley-Liss. | 2.65600 |
| 17723 | 114797 | COVID19(2023년) | ppm | Term | ppm | abstract | 30945 | https://doi.org/10.1016/j.ajem.2022.04.052 | Safety and practicality of high dose inhaled nitric oxide in emergency department COVID-19 patients | Brian Strickland|||Lorenzo Albala|||El Centro Coffey|||Ryan W Carroll|||Warren M Zapol|||Fumito Ichinose|||Lorenzo Berra|||N Stuart Harris | 202208 | Trial | PMC | {{{ Abstract }}} !!{{ Background: }} Inhaled nitric oxide (iNO) is a selective pulmonary vasodilator and mild bronchodilator that has been shown to improve systemic oxygenation, but has rarely been administered in the Emergency Department (ED). In addition to its favorable pulmonary vascular effects, in-vitro studies report that NO donors can inhibit replication of viruses, including SARS Coronavirus 2 (SARS-CoV-2). This study evaluated the administration of high-dose iNO by mask in spontaneously breathing emergency department (ED) patients with respiratory symptoms attributed to Coronavirus disease 2019 (COVID-19). !!{{ Methods: }} We designed a randomized clinical trial to determine whether 30 min of high dose iNO (250 ppm) could be safely and practically administered by emergency physicians in the ED to spontaneously-breathing patients with respiratory symptoms attributed to COVID-19. Our secondary goal was to learn if iNO could prevent the progression of mild COVID-19 to a more severe state. !!{{ Findings: }} We enrolled 47 ED patients with acute respiratory symptoms most likely due to COVID-19: 25 of 47 (53%) were randomized to the iNO treatment group; 22 of 47 (46%) to the control group (supportive care only). All patients tolerated the administration of high-dose iNO in the ED without significant complications or symptoms. Five patients receiving iNO (16%) experienced asymptomatic methemoglobinemia (MetHb) > 5%. Thirty-four of 47 (72%) subjects tested positive for SARS-CoV-2: 19 of 34 were randomized to the iNO treatment group and 15 of 34 subjects to the control group. Seven of 19 (38%) iNO patients returned to the ED, while 4 of 15 (27%) control patients did. One patient in each study arm was hospitalized: 5% in iNO treatment and 7% in controls. One patient was intubated in the iNO group. No patients in either group died. The differences between these groups were not significant. !!{{ Conclusion: }} A single dose of iNO at 250 ppm was practical and not associated with any significant adverse effects when administered in the ED by emergency physicians. Local disease control led to early study closure and prevented complete testing of COVID-19 safety and treatment outcomes measures. !!{{ Keywords: }} COVID-19; Emergency department; Nitric oxide. | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/9066706/ | 231 | 0735-6757 | The American journal of emergency medicine | Philadelphia, PA : W B Saunders. | ||
| 16003 | 114797 | COVID19(2023년) | coronavirus disease | Disease | coronavirus disease | title | 코로나바이러스 질환 | 245851 | https://doi.org/10.1507/endocrj.EJ22-0459 | Possibility of endocrine dysfunction in post coronavirus disease 2019 (COVID-19) condition | Yuki Otsuka|||Fumio Otsuka | 202211 | pubmed | None | https://pubmed.ncbi.nlm.nih.gov/36216578/ | 7177 | 0918-8959 | Endocrine journal | Tokyo : Japan Endocrine Society | ||
| 16005 | 114797 | COVID19(2023년) | dysfunction | Term | dysfunction | title | 기능 장애 | 245851 | https://doi.org/10.1507/endocrj.EJ22-0459 | Possibility of endocrine dysfunction in post coronavirus disease 2019 (COVID-19) condition | Yuki Otsuka|||Fumio Otsuka | 202211 | pubmed | None | https://pubmed.ncbi.nlm.nih.gov/36216578/ | 7177 | 0918-8959 | Endocrine journal | Tokyo : Japan Endocrine Society | ||
| 16380 | 114797 | COVID19(2023년) | NHS | Gene | NHS | title | 국민 보건 서비스 | 247862 | https://doi.org/10.1136/bmj.o3028 | NHS faces significant pressure as flu and covid cases rise | Elisabeth Mahase | 202212 | pubmed | None | https://pubmed.ncbi.nlm.nih.gov/36526297/ | 22 | 0959-8138 | The BMJ | Clinical research [ed.] London : British Medical Association. | ||
| 16746 | 114797 | COVID19(2023년) | combating | Action | combating | title | 2940 | https://doi.org/10.4155/tde-2021-0079 | Antiviral monoclonal antibody cocktails as a modern weapon in combating pandemics | Dingjiang Liu|||Mohammed Shameem | 202111 | Editorial | PMC | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/8582591/ | 147 | 2041-5990 | Therapeutic Delivery | London : Future Science. | |||
| 16379 | 114797 | COVID19(2023년) | flu | Term | flu | title | 인플루엔자 | 247862 | https://doi.org/10.1136/bmj.o3028 | NHS faces significant pressure as flu and covid cases rise | Elisabeth Mahase | 202212 | pubmed | None | https://pubmed.ncbi.nlm.nih.gov/36526297/ | 22 | 0959-8138 | The BMJ | Clinical research [ed.] London : British Medical Association. | ||
| 16743 | 114797 | COVID19(2023년) | antibody cocktail | Term | antibody cocktail | author | 항체 칵테일 | 2940 | https://doi.org/10.4155/tde-2021-0079 | Antiviral monoclonal antibody cocktails as a modern weapon in combating pandemics | Dingjiang Liu|||Mohammed Shameem | 202111 | Editorial | PMC | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/8582591/ | 147 | 2041-5990 | Therapeutic Delivery | London : Future Science. | ||
| 16745 | 114797 | COVID19(2023년) | coformulation | Term | coformulation | author | 코포 화 | 2940 | https://doi.org/10.4155/tde-2021-0079 | Antiviral monoclonal antibody cocktails as a modern weapon in combating pandemics | Dingjiang Liu|||Mohammed Shameem | 202111 | Editorial | PMC | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/8582591/ | 147 | 2041-5990 | Therapeutic Delivery | London : Future Science. | ||
| 16747 | 114797 | COVID19(2023년) | formulation | Term | Formulation | author | 공식표시 | 2940 | https://doi.org/10.4155/tde-2021-0079 | Antiviral monoclonal antibody cocktails as a modern weapon in combating pandemics | Dingjiang Liu|||Mohammed Shameem | 202111 | Editorial | PMC | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/8582591/ | 147 | 2041-5990 | Therapeutic Delivery | London : Future Science. | ||
| 16749 | 114797 | COVID19(2023년) | monoclonal antibody | Protein | monoclonal antibody | author,title | 단클론항체 | 2940 | https://doi.org/10.4155/tde-2021-0079 | Antiviral monoclonal antibody cocktails as a modern weapon in combating pandemics | Dingjiang Liu|||Mohammed Shameem | 202111 | Editorial | PMC | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/8582591/ | 147 | 2041-5990 | Therapeutic Delivery | London : Future Science. | ||
| 16751 | 114797 | COVID19(2023년) | pandemics | Term | pandemics | title | 범유행_전염병 | 2940 | https://doi.org/10.4155/tde-2021-0079 | Antiviral monoclonal antibody cocktails as a modern weapon in combating pandemics | Dingjiang Liu|||Mohammed Shameem | 202111 | Editorial | PMC | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/8582591/ | 147 | 2041-5990 | Therapeutic Delivery | London : Future Science. | ||
| 16753 | 114797 | COVID19(2023년) | SARS-CoV-2 | Virus | SARS-CoV-2 | author | 제2형 중증급성호흡기증후군 코로나바이러스 | 2940 | https://doi.org/10.4155/tde-2021-0079 | Antiviral monoclonal antibody cocktails as a modern weapon in combating pandemics | Dingjiang Liu|||Mohammed Shameem | 202111 | Editorial | PMC | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/8582591/ | 147 | 2041-5990 | Therapeutic Delivery | London : Future Science. | ||
| 17425 | 114797 | COVID19(2023년) | booster dose | Term | booster dose | title | 부스터 용량 | 19471 | https://doi.org/10.1016/S0140-6736(22)00090-3 | Breakthrough infections with SARS-CoV-2 omicron despite mRNA vaccine booster dose | Constanze Kuhlmann|||Carla Konstanze Mayer|||Mathilda Claassen|||Tongai Maponga|||Wendy A Burgers|||Roanne Keeton|||Catherine Riou|||Andrew D Sutherland|||Tasnim Suliman|||Megan L Shaw|||Wolfgang Preiser | 202202 | Article | PMC | None | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/8765759/ | 38 | 0140-6736 | Lancet (London, England) | London : Elsevier. | |
| 17901 | 114797 | COVID19(2023년) | pandemic | Term | pandemic | abstract | 범유행_전염병 | 77021 | https://doi.org/10.1016/j.ebiom.2022.104264 | Accelerating model-informed decisions for COVID-19 vaccine candidates using a model-based meta-analysis approach | Bhargava Kandala|||Nele Plock|||Akshita Chawla|||Anna Largajolli|||Seth Robey|||Kenny Watson|||Raj Thatavarti|||Sheri A Dubey|||S Y Amy Cheung|||Rik de Greef|||Julie Stone|||Jeffrey R Sachs | 202210 | {{{ Abstract }}} !!{{ Background: }} The COVID-19 pandemic has increased the need for innovative quantitative decision tools to support rapid development of safe and efficacious vaccines against SARS-CoV-2. To meet that need, we developed and applied a model-based meta-analysis (MBMA) approach integrating non-clinical and clinical immunogenicity and protection data. !!{{ Methods: }} A systematic literature review identified studies of vaccines against SARS-CoV-2 in rhesus macaques (RM) and humans. Summary-level data of 13 RM and 8 clinical trials were used in the analysis. A RM MBMA model was developed to quantify the relationship between serum neutralizing (SN) titres after vaccination and peak viral load (VL) post-challenge in RM. The translation of the RM MBMA model to a clinical protection model was then carried out to predict clinical efficacies based on RM data alone. Subsequently, clinical SN and efficacy data were integrated to develop three predictive models of efficacy - a calibrated RM MBMA, a joint (RM-Clinical) MBMA, and the clinical MBMA model. The three models were leveraged to predict efficacies of vaccine candidates not included in the model and efficacies against newer strains of SARS-CoV-2. !!{{ Findings: }} Clinical efficacies predicted based on RM data alone were in reasonable agreement with the reported data. The SN titre predicted to provide 50% efficacy was estimated to be about 21% of the mean human convalescent titre level, and that value was consistent across the three models. Clinical efficacies predicted from the MBMA models agreed with reported efficacies for two vaccine candidates (BBV152 and CoronaVac) not included in the modelling and for efficacies against delta variant. !!{{ Interpretation: }} The three MBMA models are predictive of protection against SARS-CoV-2 and provide a translational framework to enable early Go/No-Go and study design decisions using non-clinical and/or limited clinical immunogenicity data in the development of novel SARS-CoV-2 vaccines. !!{{ Funding: }} This study was funded by Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA. !!{{ Keywords: }} COVID-19; Model-based meta-analysis (MBMA); Modelling; Modelling and simulation; SARS-CoV-2; Systematic literature search; Vaccines. | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/9514977/ | 110 | 2352-3964 | EBioMedicine | [Amsterdam] : Elsevier B.V. | |||
| 17908 | 114797 | COVID19(2023년) | rhesus macaque | Term | rhesus macaque | abstract | 벵골원숭이 | 77021 | https://doi.org/10.1016/j.ebiom.2022.104264 | Accelerating model-informed decisions for COVID-19 vaccine candidates using a model-based meta-analysis approach | Bhargava Kandala|||Nele Plock|||Akshita Chawla|||Anna Largajolli|||Seth Robey|||Kenny Watson|||Raj Thatavarti|||Sheri A Dubey|||S Y Amy Cheung|||Rik de Greef|||Julie Stone|||Jeffrey R Sachs | 202210 | {{{ Abstract }}} !!{{ Background: }} The COVID-19 pandemic has increased the need for innovative quantitative decision tools to support rapid development of safe and efficacious vaccines against SARS-CoV-2. To meet that need, we developed and applied a model-based meta-analysis (MBMA) approach integrating non-clinical and clinical immunogenicity and protection data. !!{{ Methods: }} A systematic literature review identified studies of vaccines against SARS-CoV-2 in rhesus macaques (RM) and humans. Summary-level data of 13 RM and 8 clinical trials were used in the analysis. A RM MBMA model was developed to quantify the relationship between serum neutralizing (SN) titres after vaccination and peak viral load (VL) post-challenge in RM. The translation of the RM MBMA model to a clinical protection model was then carried out to predict clinical efficacies based on RM data alone. Subsequently, clinical SN and efficacy data were integrated to develop three predictive models of efficacy - a calibrated RM MBMA, a joint (RM-Clinical) MBMA, and the clinical MBMA model. The three models were leveraged to predict efficacies of vaccine candidates not included in the model and efficacies against newer strains of SARS-CoV-2. !!{{ Findings: }} Clinical efficacies predicted based on RM data alone were in reasonable agreement with the reported data. The SN titre predicted to provide 50% efficacy was estimated to be about 21% of the mean human convalescent titre level, and that value was consistent across the three models. Clinical efficacies predicted from the MBMA models agreed with reported efficacies for two vaccine candidates (BBV152 and CoronaVac) not included in the modelling and for efficacies against delta variant. !!{{ Interpretation: }} The three MBMA models are predictive of protection against SARS-CoV-2 and provide a translational framework to enable early Go/No-Go and study design decisions using non-clinical and/or limited clinical immunogenicity data in the development of novel SARS-CoV-2 vaccines. !!{{ Funding: }} This study was funded by Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA. !!{{ Keywords: }} COVID-19; Model-based meta-analysis (MBMA); Modelling; Modelling and simulation; SARS-CoV-2; Systematic literature search; Vaccines. | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/9514977/ | 110 | 2352-3964 | EBioMedicine | [Amsterdam] : Elsevier B.V. | |||
| 21298 | 114797 | COVID19(2023년) | While | Term | While | abstract | 245064 | https://doi.org/10.1001/jamaophthalmol.2022.3234 | Association of COVID-19 Infection With Wearing Glasses in a High-Prevalence Area in Denmark and Sweden | Rasmus Gregersen|||Rikke Kart Jacobsen|||Jannie Laursen|||Regine Mobech|||Sisse Rye Ostrowski|||Kasper Iversen|||Janne Petersen | 202210 | pubmed | {{ Importance: }} Observational studies have indicated that glasses might protect against contracting COVID-19 through reduced airborne and contact transmission. !!{{ Objective: }} To investigate the association between wearing one's own glasses with contracting COVID-19 when adjusting for relevant confounders. !!{{ Design, setting, and participants: }} This cohort study was conducted during the first wave of the COVID-19 pandemic (June to August 2020) in Denmark and Sweden, where personal protective equipment was not recommended for the general population at the time. Employees at Falck, an international rescue corps with different job functions (ambulance, health care, office, and field staff, firefighters, and roadside assistance) participated in the study. !!{{ Exposures: }} The main exposure was wearing glasses (also including contact lenses and reading glasses), which was assessed in a questionnaire. Persons wearing glasses were compared with those who did not wear glasses (ie, nonusers). To adjust for potential confounders, information on age, sex, job function, and number of workday contacts were included. !!{{ Main outcomes and measures: }} The outcome was COVID-19 infection before (positive polymerase chain reaction test) or during the study period (biweekly voluntary tests with a rapid test). The investigated hypothesis was formulated after collecting the data. !!{{ Results: }} A total of 1279 employees in Denmark and 841 in Sweden were included (839 [39.6%] female and 1281 [60.4%] male; 20.5% were aged <40 years; 57.0%, 40-60 years, and 22.5%, >60 years). Of these, 829 individuals (64.8%) in Denmark and 619 (73.6%) in Sweden wore glasses. Wearing glasses was inversely associated with COVID-19 infection in the Swedish cohort (odds ratio [OR], 0.61 [95% CI, 0.37-0.99]; P = .047; seroprevalence, 9.3%) but not in the Danish cohort (OR, 1.14 [95% CI, 0.53-2.45]; P = .73; seroprevalence, 2.4%). Adjusting for age, sex, job function, and number of workday contacts in Sweden, wearing glasses no longer was associated with COVID-19 infection (OR, 0.64 [95% CI, 0.37-1.11]; P = .11). When stratifying by job function, a large difference was observed among office staff (OR, 0.20 [95% CI, 0.06-0.70]; P = .01) but not ambulance staff (OR, 0.83 [95% CI, 0.41-1.67]; P = .60) nor health care staff (OR, 0.89 [95% CI, 0.35-2.30]; P = .81). !!{{ Conclusions and relevance: }} While wearing one's glasses was inversely associated with COVID-19 in Sweden in an unadjusted analysis, an association no longer was identified when adjusting for confounders. These results provide inconclusive findings regarding whether wearing one's own glasses is associated with a decreased risk of COVID-19 infections. | https://pubmed.ncbi.nlm.nih.gov/36006635/ | 915 | 2168-6165 | JAMA ophthalmology | Chicago, IL : American Medical Association | |||
| 21296 | 114797 | COVID19(2023년) | Swedish | Term | Swedish | abstract | 245064 | https://doi.org/10.1001/jamaophthalmol.2022.3234 | Association of COVID-19 Infection With Wearing Glasses in a High-Prevalence Area in Denmark and Sweden | Rasmus Gregersen|||Rikke Kart Jacobsen|||Jannie Laursen|||Regine Mobech|||Sisse Rye Ostrowski|||Kasper Iversen|||Janne Petersen | 202210 | pubmed | {{ Importance: }} Observational studies have indicated that glasses might protect against contracting COVID-19 through reduced airborne and contact transmission. !!{{ Objective: }} To investigate the association between wearing one's own glasses with contracting COVID-19 when adjusting for relevant confounders. !!{{ Design, setting, and participants: }} This cohort study was conducted during the first wave of the COVID-19 pandemic (June to August 2020) in Denmark and Sweden, where personal protective equipment was not recommended for the general population at the time. Employees at Falck, an international rescue corps with different job functions (ambulance, health care, office, and field staff, firefighters, and roadside assistance) participated in the study. !!{{ Exposures: }} The main exposure was wearing glasses (also including contact lenses and reading glasses), which was assessed in a questionnaire. Persons wearing glasses were compared with those who did not wear glasses (ie, nonusers). To adjust for potential confounders, information on age, sex, job function, and number of workday contacts were included. !!{{ Main outcomes and measures: }} The outcome was COVID-19 infection before (positive polymerase chain reaction test) or during the study period (biweekly voluntary tests with a rapid test). The investigated hypothesis was formulated after collecting the data. !!{{ Results: }} A total of 1279 employees in Denmark and 841 in Sweden were included (839 [39.6%] female and 1281 [60.4%] male; 20.5% were aged <40 years; 57.0%, 40-60 years, and 22.5%, >60 years). Of these, 829 individuals (64.8%) in Denmark and 619 (73.6%) in Sweden wore glasses. Wearing glasses was inversely associated with COVID-19 infection in the Swedish cohort (odds ratio [OR], 0.61 [95% CI, 0.37-0.99]; P = .047; seroprevalence, 9.3%) but not in the Danish cohort (OR, 1.14 [95% CI, 0.53-2.45]; P = .73; seroprevalence, 2.4%). Adjusting for age, sex, job function, and number of workday contacts in Sweden, wearing glasses no longer was associated with COVID-19 infection (OR, 0.64 [95% CI, 0.37-1.11]; P = .11). When stratifying by job function, a large difference was observed among office staff (OR, 0.20 [95% CI, 0.06-0.70]; P = .01) but not ambulance staff (OR, 0.83 [95% CI, 0.41-1.67]; P = .60) nor health care staff (OR, 0.89 [95% CI, 0.35-2.30]; P = .81). !!{{ Conclusions and relevance: }} While wearing one's glasses was inversely associated with COVID-19 in Sweden in an unadjusted analysis, an association no longer was identified when adjusting for confounders. These results provide inconclusive findings regarding whether wearing one's own glasses is associated with a decreased risk of COVID-19 infections. | https://pubmed.ncbi.nlm.nih.gov/36006635/ | 915 | 2168-6165 | JAMA ophthalmology | Chicago, IL : American Medical Association | |||
| 18213 | 114797 | COVID19(2023년) | the SARS-CoV-2 virus | Virus | SARS-CoV-2 virus | abstract | SARS-COV-2 바이러스 | 79541 | https://doi.org/10.1093/bioinformatics/btac621 | Systematic comparison of ranking aggregation methods for gene lists in experimental results | Bo Wang|||Andy Law|||Tim Regan|||Nicholas Parkinson|||Joby Cole|||Clark D Russell|||David H Dockrell|||Michael U Gutmann|||J Kenneth Baillie | 202210 | {{{ Abstract }}} !!{{ Motivation: }} A common experimental output in biomedical science is a list of genes implicated in a given biological process or disease. The gene lists resulting from a group of studies answering the same, or similar, questions can be combined by ranking aggregation methods to find a consensus or a more reliable answer. Evaluating a ranking aggregation method on a specific type of data before using it is required to support the reliability since the property of a dataset can influence the performance of an algorithm. Such evaluation on gene lists is usually based on a simulated database because of the lack of a known truth for real data. However, simulated datasets tend to be too small compared to experimental data and neglect key features, including heterogeneity of quality, relevance and the inclusion of unranked lists. !!{{ Results: }} In this study, a group of existing methods and their variations that are suitable for meta-analysis of gene lists are compared using simulated and real data. Simulated data were used to explore the performance of the aggregation methods as a function of emulating the common scenarios of real genomic data, with various heterogeneity of quality, noise level and a mix of unranked and ranked data using 20 000 possible entities. In addition to the evaluation with simulated data, a comparison using real genomic data on the SARS-CoV-2 virus, cancer (non-small cell lung cancer) and bacteria (macrophage apoptosis) was performed. We summarize the results of our evaluation in a simple flowchart to select a ranking aggregation method, and in an automated implementation using the meta-analysis by information content algorithm to infer heterogeneity of data quality across input datasets. !!{{ Availability and implementation: }} The code for simulated data generation and running edited version of algorithms: https://github.com/baillielab/comparison_of_RA_methods. Code to perform an optimal selection of methods based on the results of this review, using the MAIC algorithm to infer the characteristics of an input dataset, can be downloaded here: https://github.com/baillielab/maic. An online service for running MAIC: https://baillielab.net/maic. !!{{ Supplementary information: }} Supplementary data are available at Bioinformatics online. | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/9620830/ | 517 | 1367-4803 | Bioinformatics | Oxford : Oxford University Press | |||
| 18496 | 114797 | COVID19(2023년) | Cardiac | Term | Cardiac | title | 심장병환자 | 232113 | https://doi.org/10.1016/j.athoracsur.2021.02.067 | COVID-19 and Cardiac Surgery: Still Many Questions and Much Work to Do | Carlo Maria Rosati|||Chan Tran N Nguyen|||Shinichi Fukuhara | 202202 | Comment | pubmed | None | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/7942144/ | 1828 | 0003-4975 | The Annals of thoracic surgery | Amsterdam : Elsevier. | |
| 18553 | 114797 | COVID19(2023년) | activities | Action | activities | abstract | 233394 | https://doi.org/10.1093/heapol/czab089 | COVID-19 Preparedness and Response Plans from 106 countries: a review from a health systems resilience perspective | Saqif Mustafa|||Yu Zhang|||Zandile Zibwowa|||Redda Seifeldin|||Louis Ako-Egbe|||Geraldine McDarby|||Edward Kelley|||Sohel Saikat | 202202 | Review | pubmed | Coronavirus disease (COVID-19) has exposed long-standing fragmentation in health systems strengthening efforts for health security and universal health coverage while these objectives are largely interdependent and complementary. In this prevailing background, we reviewed countries' COVID-19 Preparedness and Response Plans (CPRPs) to assess the extent of integration of non-COVID-19 essential health service continuity considerations alongside emergency response activities. We searched for COVID-19 planning documents from governments and ministries of health, World Health Organization (WHO) country offices and United Nations (UN) country teams. We developed document review protocols using global guidance from the WHO and UN and the health systems resilience literature. After screening, we analysed 154 CPRPs from 106 countries. The majority of plans had a high degree of alignment with pillars of emergency response such as surveillance (99%), laboratory systems (96%) and COVID-19-specific case management (97%). Less than half considered maintaining essential health services (47%); 41% designated a mechanism for health system-wide participation in emergency planning; 34% considered subnational service delivery; 95% contained infection prevention and control (IPC) activities and 29% considered quality of care; and 24% were budgeted for and 7% contained monitoring and evaluation of essential health services. To improve, ongoing and future emergency planning should proactively include proportionate activities, resources and monitoring for essential health services to reduce excess mortality and morbidity. Specifically, this entails strengthening subnational health services with local stakeholder engagement in planning; ensuring a dedicated focus in emergency operations structures to maintain health systems resilience for non-emergency health services; considering all domains of quality in health services along with IPC; and building resilient monitoring capacity for timely and reliable tracking of health systems functionality including service utilization and health outcomes. An integrated approach to planning should be pursued as health systems recover from COVID-19 disruptions and take actions to build back better. | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/8385840/ | 2015 | 0268-1080 | Health policy and planning | [Oxford] : Oxford University Press in association with the London School of Hygiene and Tropical Medicine | ||
| 18637 | 114797 | COVID19(2023년) | care | Term | care | abstract | 돌봄 | 234718 | https://doi.org/10.1080/14767058.2021.1986482 | Breastfeeding supportive practices in European hospitals during the COVID-19 pandemic | Anne Merewood|||Riccardo Davanzo|||Maetal Haas-Kogan|||Giulia Vertecchi|||Camilla Gizzi|||Fabio Mosca|||Laura Burnham|||Corrado Moretti | 202212 | pubmed | {{ Introduction: }} During the first year of the COVID-19 pandemic, international recommendations and guidelines regarding breastfeeding-supportive hospital practices changed frequently. For example, some recommended separation of mothers and infants; others, feeding pumped milk instead of milk fed directly from the breast. Many recommendations were inconsistent or in direct conflict with each other. Guidance from UENPS (the Union of European Neonatal and Perinatal Societies) published in April 2020 recommended rooming in and direct breastfeeding where feasible, under strict measures of infection control, for women who were COVID-19 positive or under investigation for COVID-19. !!{{ Key findings: }} Our study assessed data from respondents from 124 hospitals in 22 nations, with over 1000 births per year, who completed a survey on practices during the COVID-19 epidemic, as they related to the World Health Organization (WHO) Ten Steps to Successful Breastfeeding, considered to be the gold standard for breastfeeding support. The survey was conducted in the fall of 2020/winter of 2021. Overall 88% of responding hospitals had managed COVID positive mothers, and 7% had treated over 50 birthing women with confirmed COVID-19. The biggest change to hospital policy related to visitation policies, with 38% of hospitals disallowing all visitors for birthing women, and 19% shortening the postpartum stay. Eight hospitals (6%) recommended formula feeding instead of breastfeeding for women who tested positive for COVID-19 or were under investigation, whereas 73% continued to recommend direct, exclusive breastfeeding, but with some form of protection such as a mask or hand sanitizer for the mother or cleaning the breast before the feed. While 6% of hospitals discontinued rooming in, 31% strengthened their rooming in policy (keeping mothers and their babies together in the same room) to protect infants against possible exposure to the virus elsewhere in the hospital . Overall, 72% of hospitals used their country's national guidelines when making policy, 31% used WHO guidelines and 22% UENPS/SIN guidelines. Many European hospitals relied on more than one accredited source. !!{{ Discussion: }} Our most concerning finding was that 6% of hospitals recommended formula feeding for COVID positive mothers, a measure that was later shown to be potentially harmful, as protection against the virus is transmitted through human milk. It is encouraging to note that a third of hospitals strengthened rooming in measures. Especially given the emergence of the highly transmissible Delta variant, the situation around postnatal care in maternity hospitals requires ongoing monitoring and may require proactive investment to regain pre-COVID era practices. | https://pubmed.ncbi.nlm.nih.gov/34645354/ | 2363 | The journal of maternal-fetal & neonatal medicine | ||||
| 18638 | 114797 | COVID19(2023년) | changed | Action | changed | abstract | 234718 | https://doi.org/10.1080/14767058.2021.1986482 | Breastfeeding supportive practices in European hospitals during the COVID-19 pandemic | Anne Merewood|||Riccardo Davanzo|||Maetal Haas-Kogan|||Giulia Vertecchi|||Camilla Gizzi|||Fabio Mosca|||Laura Burnham|||Corrado Moretti | 202212 | pubmed | {{ Introduction: }} During the first year of the COVID-19 pandemic, international recommendations and guidelines regarding breastfeeding-supportive hospital practices changed frequently. For example, some recommended separation of mothers and infants; others, feeding pumped milk instead of milk fed directly from the breast. Many recommendations were inconsistent or in direct conflict with each other. Guidance from UENPS (the Union of European Neonatal and Perinatal Societies) published in April 2020 recommended rooming in and direct breastfeeding where feasible, under strict measures of infection control, for women who were COVID-19 positive or under investigation for COVID-19. !!{{ Key findings: }} Our study assessed data from respondents from 124 hospitals in 22 nations, with over 1000 births per year, who completed a survey on practices during the COVID-19 epidemic, as they related to the World Health Organization (WHO) Ten Steps to Successful Breastfeeding, considered to be the gold standard for breastfeeding support. The survey was conducted in the fall of 2020/winter of 2021. Overall 88% of responding hospitals had managed COVID positive mothers, and 7% had treated over 50 birthing women with confirmed COVID-19. The biggest change to hospital policy related to visitation policies, with 38% of hospitals disallowing all visitors for birthing women, and 19% shortening the postpartum stay. Eight hospitals (6%) recommended formula feeding instead of breastfeeding for women who tested positive for COVID-19 or were under investigation, whereas 73% continued to recommend direct, exclusive breastfeeding, but with some form of protection such as a mask or hand sanitizer for the mother or cleaning the breast before the feed. While 6% of hospitals discontinued rooming in, 31% strengthened their rooming in policy (keeping mothers and their babies together in the same room) to protect infants against possible exposure to the virus elsewhere in the hospital . Overall, 72% of hospitals used their country's national guidelines when making policy, 31% used WHO guidelines and 22% UENPS/SIN guidelines. Many European hospitals relied on more than one accredited source. !!{{ Discussion: }} Our most concerning finding was that 6% of hospitals recommended formula feeding for COVID positive mothers, a measure that was later shown to be potentially harmful, as protection against the virus is transmitted through human milk. It is encouraging to note that a third of hospitals strengthened rooming in measures. Especially given the emergence of the highly transmissible Delta variant, the situation around postnatal care in maternity hospitals requires ongoing monitoring and may require proactive investment to regain pre-COVID era practices. | https://pubmed.ncbi.nlm.nih.gov/34645354/ | 2363 | The journal of maternal-fetal & neonatal medicine | |||||
| 19310 | 114797 | COVID19(2023년) | COVID-19 | Disease | COVID-19 | title,abstract | 코로나-19 | 237950 | https://doi.org/10.7326/M22-0403 | Outpatient Evaluation and Management of COVID-19 | Christine Laine|||Deborah Cotton|||Darilyn V Moyer | 202204 | pubmed | This article summarizes the ACP/ Annals COVID-19 Forum VIII held on 9 February 2022. | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/9022138/ | 909 | 0003-4819 | Annals of internal medicine | Philadelphia, PA : American College of Physicians--American Society of Internal Medicine. | ||
| 19586 | 114797 | COVID19(2023년) | Reaction | Term | reaction | title | 238838 | https://doi.org/10.1001/jamapediatrics.2022.0088 | Hypersensitivity Reactions to COVID-19 Vaccines-Identify High-risk Children and Vaccinate the Rest | Natalia Fernandez-Davila|||Margaret G Taylor|||Sara Anvari | 202205 | pubmed | None | https://pubmed.ncbi.nlm.nih.gov/35254412/ | 747 | 2168-6203 | JAMA Pediatrics | Chicago, IL : American Medical Association | |||
| 19514 | 114797 | COVID19(2023년) | antibody | Protein | antibody | abstract | 항체 | 238775 | https://doi.org/10.1161/STROKEAHA.121.036824 | Cerebral Venous Thrombosis in Patients With Heparin-Induced Thrombocytopenia a Systematic Review | Diana Aguiar de Sousa|||Michele Romoli|||Mayte S?nchez Van Kammen|||Mirjam R Heldner|||Andrea Zini|||Jonathan M Coutinho|||Marcel Arnold|||Jos? M Ferro | 202206 | Meta-Analysis | pubmed | {{ Background: }} Cerebral venous thrombosis (CVT) has recently been reported as a common thrombotic manifestation in association with vaccine-induced thrombotic thrombocytopenia, a syndrome that mimics heparin-induced thrombocytopenia (HIT) and occurs after vaccination with adenovirus-based SARS-CoV-2 vaccines. We aimed to systematically review the incidence, clinical features, and prognosis of CVT occurring in patients with HIT. !!{{ Methods: }} The study protocol was registered with PROSPERO (CRD42021249652). MEDLINE, EMBASE and Cochrane CENTRAL were searched up to June 1, 2021 for HIT case series including >20 patients, or any report of HIT-related CVT. Demographic, neuroradiological, clinical, and mortality data were retrieved. Meta-analysis of proportions with random-effect modeling was used to derive rate of CVT in HIT and in-hospital mortality. Pooled estimates were compared with those for CVT without HIT and HIT without CVT, to determine differences in mortality. !!{{ Results: }} From 19073 results, we selected 23 case series of HIT (n=1220) and 27 cases of HIT-related CVT (n=27, 71% female). CVT developed in 1.6% of 1220 patients with HIT (95% CI,1.0%-2.5%, I ^{2}=0%). Hemorrhagic brain lesions occurred in 81.8% of cases of HIT-related CVT and other concomitant thrombosis affecting other vascular territory was reported in 47.8% of cases. In-hospital mortality was 33.3%. HIT-related CVT carried a 29% absolute increase in mortality rate compared with historical CVT controls (33.3% versus 4.3%, P <0.001) and a 17.4% excess mortality compared with HIT without CVT (33.3% versus 15.9%, P =0.046). !!{{ Conclusions: }} CVT is a rare thrombotic manifestation in patients with HIT. HIT-related CVT has higher rates of intracerebral hemorrhage and a higher mortality risk, when compared with CVT in historical controls. The recently reported high frequency of CVT in patients with vaccine-induced thrombotic thrombocytopenia was not observed in HIT, suggesting that additional pathophysiological mechanisms besides anti-platelet factor-4 antibodies might be involved in vaccine-induced thrombotic thrombocytopenia-related CVT. | https://pubmed.ncbi.nlm.nih.gov/35240862/ | 1171 | 0039-2499 | Stroke | Baltimore, Md. : Lippincott Williams & Wilkins. | |
| 20893 | 114797 | COVID19(2023년) | RNA | Molecule | RNA | abstract | 리보핵산 | 243984 | https://doi.org/10.1016/j.compbiolchem.2022.107721 | A computational essential dynamics approach to investigate structural influences of ligand binding on Papain like protease from SARS-CoV-2 | Ekampreet Singh|||Rajat Kumar Jha|||Rameez Jabeer Khan|||Ankit Kumar|||Monika Jain|||Jayaraman Muthukumaran|||Amit Kumar Singh | 202208 | pubmed | Papain like protease (PLpro) is a cysteine protease from the coronaviridae family of viruses. Coronaviruses possess a positive sense, single-strand RNA, leading to the translation of two viral polypeptides containing viral structural, non-structural and accessory proteins. PLpro is responsible for the cleavage of nsp1-3 from the viral polypeptide. PLpro also possesses deubiquitinating and deISGlyating activity, which sequesters the virus from the host's immune system. This indispensable attribute of PLpro makes it a protein of interest as a drug target. The present study aims to analyze the structural influences of ligand binding on PLpro. First, PLpro was screened against the ZINC-in-trials library, from which four lead compounds were identified based on estimated binding affinity and interaction patterns. Next, based on molecular docking results, ZINC000000596945, ZINC000064033452 and VIR251 (control molecule) were subjected to molecular dynamics simulation. The study evaluated global and essential dynamics analyses utilising principal component analyses, dynamic cross-correlation matrix, free energy landscape and time-dependant essential dynamics to predict the structural changes observed in PLpro upon ligand binding in a simulated environment. The MM/PBSA-based binding free energy calculations of the two selected molecules, ZINC000000596945 (-41.23 ± 3.70 kcal/mol) and ZINC000064033452 (-25.10 ± 2.65 kcal/mol), displayed significant values which delineate them as potential inhibitors of PLpro from SARS-CoV-2. | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/9238113/ | 402 | 1476-9271 | Computational biology and chemistry | Oxford : Elsevier. | ||
| 20896 | 114797 | COVID19(2023년) | selected | Action | selected | abstract | 243984 | https://doi.org/10.1016/j.compbiolchem.2022.107721 | A computational essential dynamics approach to investigate structural influences of ligand binding on Papain like protease from SARS-CoV-2 | Ekampreet Singh|||Rajat Kumar Jha|||Rameez Jabeer Khan|||Ankit Kumar|||Monika Jain|||Jayaraman Muthukumaran|||Amit Kumar Singh | 202208 | pubmed | Papain like protease (PLpro) is a cysteine protease from the coronaviridae family of viruses. Coronaviruses possess a positive sense, single-strand RNA, leading to the translation of two viral polypeptides containing viral structural, non-structural and accessory proteins. PLpro is responsible for the cleavage of nsp1-3 from the viral polypeptide. PLpro also possesses deubiquitinating and deISGlyating activity, which sequesters the virus from the host's immune system. This indispensable attribute of PLpro makes it a protein of interest as a drug target. The present study aims to analyze the structural influences of ligand binding on PLpro. First, PLpro was screened against the ZINC-in-trials library, from which four lead compounds were identified based on estimated binding affinity and interaction patterns. Next, based on molecular docking results, ZINC000000596945, ZINC000064033452 and VIR251 (control molecule) were subjected to molecular dynamics simulation. The study evaluated global and essential dynamics analyses utilising principal component analyses, dynamic cross-correlation matrix, free energy landscape and time-dependant essential dynamics to predict the structural changes observed in PLpro upon ligand binding in a simulated environment. The MM/PBSA-based binding free energy calculations of the two selected molecules, ZINC000000596945 (-41.23 ± 3.70 kcal/mol) and ZINC000064033452 (-25.10 ± 2.65 kcal/mol), displayed significant values which delineate them as potential inhibitors of PLpro from SARS-CoV-2. | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/9238113/ | 402 | 1476-9271 | Computational biology and chemistry | Oxford : Elsevier. | |||
| 20166 | 114797 | COVID19(2023년) | death | Disease | death | title | 사망 | 241035 | https://doi.org/10.1136/bmj.o1147 | Covid-19: US passes one million deaths as mask mandates return | Janice Hopkins Tanne | 202205 | pubmed | None | https://pubmed.ncbi.nlm.nih.gov/35523444/ | 22 | 0959-8138 | The BMJ | Clinical research [ed.] London : British Medical Association. | ||
| 25691 | 114797 | COVID19(2023년) | diabete | Disease | diabete | title | 당뇨병 | 240025 | https://doi.org/10.1093/eurheartj/ehac196 | Increased risk of incident diabetes in patients with long COVID | Francesco Paneni|||Carlo Patrono | 202206 | pubmed | None | https://pubmed.ncbi.nlm.nih.gov/35417544/ | 957 | 0195-668X | European heart journal | Oxford : Oxford University Press. | ||
| 21897 | 114797 | COVID19(2023년) | SARS-CoV-2 infection | Disease | SARS-CoV-2 infection | title | SARS-COV-2 감염 | 247205 | https://doi.org/10.1007/s40520-022-02304-8 | When to opt for preemptive anticoagulation with SARS-CoV-2 infection in the long-term care facilities | Nadia Mujahid|||Ashna Rajan|||Yasin Abul|||Naga Venkata Rama Krishna Vura|||Iva Neupane|||Kerry LaPlante|||Stefan Gravenstein | 202212 | pubmed | None | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/9702642/ | 464 | 1594-0667 | Aging Clinical and Experimental Research | Berlin : Springer. | ||
| 24290 | 114797 | COVID19(2023년) | nonmaleficence. | Term | nonmaleficence. | author | 231633 | https://doi.org/10.1177/0897190020942658 | Hydroxychloroquine Alternatives for Chronic Disease: Response to a Growing Shortage Amid the Global COVID-19 Pandemic | Sameeha S Husayn|||Jeremy D Brown|||Colby L Presley|||Kelsey Boghean|||Jacquelyn D Waller | 202202 | Review | pubmed | !! With the emergence of a novel severe acute respiratory syndrome coronavirus, investigators worldwide are scrambling to identify appropriate treatment modalities, develop accurate testing, and produce a vaccine. To date, effective treatment remains elusive. Chloroquine phosphate and hydroxychloroquine sulfate (HCQ), well-known antimalarial drugs effective in the treatment of systemic lupus erythematosus, rheumatoid arthritis, porphyria cutanea tarda, and chronic Q fever, are currently under investigation. The United States Food and Drug Administration recently issued an Emergency Use Authorization for CQ and HCQ use in the treatment of coronavirus disease 2019 (COVID-19). With spikes in HCQ use and demand, ethical considerations encompassing appropriate use, patient autonomy, nonmaleficence, and distributive justice abound. As drug experts, pharmacists are uniquely positioned to advocate for patients with chronic conditions necessitating HCQ use, assist in the appropriate prescribing of HCQ for COVID-19, and ensure patients and health care professionals are continually educated during this public health crisis. This review highlights the worldwide pandemic, describes appropriate HCQ use for chronic conditions, highlights available alternatives, and deliberates evolving ethical questions. With assistance from colleagues, state boards of pharmacy, and national organizations, pharmacists ensure the just distribution of valuable pharmaceuticals to patients having COVID-19 while supporting the needs of patients requiring HCQ for chronic conditions. | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/8819554/ | 2464 | Journal of pharmacy practice |
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